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Chromosome-level genome assembly of Oncomelania hupensis: the intermediate snail host of Schistosoma japonicum

Infectious Diseases of Poverty 2024年第1期13卷 16-26页

作者： Qin Liu Lei Duan Yun-Hai Guo Li-Min Yang Yi Zhang Shi-Zhu Li Shan Lv Wei hu nan-Sheng Chen Xiao-Nong Zhou National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Centerfor Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesShanghai 200025People's Republic of China School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025People's Republic of China School of Life Science Fudan UniversityShanghai 200438People's Republic of China CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdaoShandong 266071People'sRepublicofChina

Background Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China, the Philippines and *** hupensis (Gastropoda: Pomatiopsidae) is the unique intermediate host ofS. japonicum. A complete genome sequence ofO. hupensis will enable the fundamental understanding of snail biology as well as its co-evolution with theS. japonicum parasite. Assembling a high-quality reference genome ofO. hupehensis will provide data for further research on the snail biology and controlling the spread ofS. *** The draft genome was de novo assembly using the long-read sequencing technology (PacBio Sequel II) and corrected with Illumina sequencing data. Then, using Hi-C sequencing data, the genome was assembled at the chromosomal level. CAFE was used to do analysis of contraction and expansion of the gene family and CodeML module in PAML was used for positive selection analysis in protein coding *** A total length of 1.46 Gb high-qualityO. hupensis genome with 17 unique full-length chromosomes (2n = 34) of the individual including a contig N50 of 1.35 Mb and a scaffold N50 of 75.08 Mb. Additionally, 95.03% of these contig sequences were anchored in 17 chromosomes. After scanning the assembled genome, a total of 30,604 protein-coding genes were predicted. Among them, 86.67% were functionally annotated. Further phylogenetic analysis revealed thatO. hupensis was separated from a common ancestor ofPomacea canaliculata andBellamya purificata approximately 170 million years ago. Comparing the genome ofO. hupensis with its most recent common ancestor, it showed 266 significantly expanded and 58 significantly contracted gene families (P < 0.05). Functional enrichment of the expanded gene families indicated that they were mainly involved with intracellular, DNA-mediated transposition, DNA integration and transposase *** Integrated use of multiple sequencing technol

关键词： Schistosomiasis Schistosoma japonicum Oncomelania hupensis Chromosome-level genome

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我国高职专业认证的价值意蕴、现实挑战与突破路径

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教育与职业 2024年第11期1059卷 55-62页

作者：郭丽君胡楠湖南农业大学教育学院湖南长沙410128

高职专业认证是深化职业教育质量评价体系的必然之举。高职专业认证的实施有助于构建适应中国特色的职业教育人才培养体系,促进产业发展与社会需求的有效衔接,推动专业建设水平稳步提升,并促进人才全球跨国合作与交流。然而,当前我国高... 详细信息

高职专业认证是深化职业教育质量评价体系的必然之举。高职专业认证的实施有助于构建适应中国特色的职业教育人才培养体系,促进产业发展与社会需求的有效衔接,推动专业建设水平稳步提升,并促进人才全球跨国合作与交流。然而,当前我国高职专业认证面临诸多挑战,如地域差异与产业发展的平衡障碍、理念阻碍与资源瓶颈的内在矛盾以及认证理念与评估方法的杂糅风险。因此,我国需构建“政府引导、多方联动、跨界融合”的全国性高职专业认证机构,完善高职院校参与专业认证的资源驱动机制,推动认证模式由传统的管理思维向协同治理的转变,从而促进中国特色高职专业认证体系的建设与发展。

关键词：专业认证职业教育体系建设人才培养质量保障内涵建设

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Transcriptional landscape of cotton roots in response to salt stress at single-cell resolution

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Plant Communications 2024年第2期5卷 46-66页

作者： Pengtao Li Qiankun Liu Yangyang Wei Chaozhu Xing Zhongping Xu Fang Ding Yuling Liu Quanwei Lu nan hu Tao Wang Xiangqian Zhu Shuang Cheng Zhaoguo Li Zilin Zhao Yanfang Li Jiangping Han Xiaoyan Cai Zhongli Zhou Kunbo Wang Baohong Zhang Fang Liu Shuangxia Jin Renhai Peng College of Biology and Food Engineering Anyang Institute of TechnologyAnyangHenan 455000China State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China Research Base Anyang Institute of TechnologyState Key Laboratory of Cotton BiologyAnyang 455000HenanChina School of Life Sciences Zhengzhou UniversityZhengzhouHenan 450001China hubei Hongshan Laboratory National Key Laboratory of Crop Genetic ImprovementHuazhong Agricultural UniversityWuhanHubeiChina hubei Key Laboratory of Plant Pathology Huazhong Agricultural UniversityWuhanHubei 430070China Department of Biology East Carolina UniversityGreenvilleNC 27858USA

Increasing soil salinization has led to severe reductions in plant yield and quality,and investigating the mo-lecular mechanism of salt stress response is therefore an urgent *** this study,we systematically analyzed the response of cotton roots to salt stress using single-cell transcriptomics technology;56281 high-quality cells were obtained from 5-day-old lateral root tips of Gossypium arboreum under natural growth conditions and different salt *** cell types with an array of novel marker genes were identified and confirmed by in situ RNA hybridization,and pseudotime analysis of some specific cell types revealed their potential differentiation *** changes in cell numbers under salt stress were observed for outer epidermal and inner endodermal cells,which were significantly enriched in response to stress,amide biosynthetic process,glutathione metabolism,and glycolysis/*** of differentially expressed genes identified in multiple comparisons revealed other functional ag-gregations concentrated on plant-type primary cell wall biogenesis,defense response,phenylpropanoid biosynthesis,and metabolic *** candidate differentially expressed genes encoding transcrip-tion factors or associated with plant hormones also responsive to salt stress were identified,and the func-tion of Ga03G2153,annotated as auxin-responsive GH3.6,was confirmed by virus-induced gene *** GaGH3.6-silenced plants showed a severe stress-susceptible phenotype,and physiological and biochemical measurements indicated that they suffered more significant oxidative *** results suggest that GaGH3.6 might participate in cotton salt tolerance by regulating redox *** thus construct a transcriptional atlas of salt-stressed cotton roots at single-cell resolution,enabling us to explore cellular heterogeneity and differentiation trajectories and providing valuable insights into the mo-lecular mechanisms that underlie plan

关键词： cotton salt stress scRNA-seq root cell types virus-induced gene silencing

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Insights into varicella-zoster virus assembly from the B-and C-capsid at near-atomic resolution structures

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hLife 2024年第2期2卷 64-74页

作者： Lei Cao nan Wang Zhe Lv Wenyuan Chen Zhonghao Chen Lifei Song Xueyan Sha Guiqiang Wang Yaling hu Xiaojun Lian Guoliang Cui Jinyan Fan Yaru Quan Hongrong Liu Hai Hou Xiangxi Wang CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijingChina Key Laboratory for Matter Microstructure and Function of hunan Province Key Laboratory of Low-dimensional Quantum Structures and Quantum ControlSchool of Physics and ElectronicsHunan Normal UniversityHunanChina Institute of Medical Research Northwestern Polytechnical UniversityShanxiChina Sinovac(Dalian)Vaccine Technology Co. Ltd.LiaoningChina Sinovac Biotech Ltd. BeijingChina National Institutes for Food and Drug Control BeijingChina

Varicella-zoster is a highly communicable virus that can be transmitted through the airborne *** one quarter of people are infected with this *** studies have described the structure of A-capsid and a blurred reconstruction of the C-capsid with icosahedral *** this study,we have determined the more precise detailed structures of the varicella-zoster virus(VZV)B-and C-capsid in icosahedral symmetry using a combination of block-based reconstruction and symmetry relaxation *** addition,we are reporting structural details of the portal vertex reconstructions in five-fold symmetry and portal reconstructions in twelve-fold *** structures unveil the basis for the high thermal stability of the VZV *** conformational flexibility of structural elements of the capsid plays a role in the assembly of the capsid and drives processes critical for the viral life *** results of the study open up new avenues for the development of drugs against a highly prevalent and contagious pathogen.

关键词： varicella-zoster virus capsid structure virus assembly

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Current-carrying tribological behavior of C/Cu contact pairs in extreme temperature and humidity environments for railway catenary systems

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Science China(Technological Sciences) 2024年第8期67卷 2537-2548页

作者： SHEN MingXue JI Dehui hu Qiang XIAO Li LI QiuPing State Key Laboratory of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong UniversityNanchang 330013China School of Materials Science and Engineering East China Jiaotong UniversityNanchang 330013China Institute of Applied Physics Jiangxi Academy of SciencesNanchang 330095China

Many current-carrying contact pairs, such as those found in pantograph-catenary systems, operate in open environments and are susceptible to significant external interference from temperature and humidity variations. This study investigated the evolution of the friction coefficient and contact resistance of C/Cu contact pairs under alternating temperature, humidity, and current conditions. Through experimentation, the wear rate and microtopography of the worn surface were analyzed under various constant parameters. Subsequently, the differences in tribological behavior and current-carrying characteristics of the contact pairs under these three parameters were explored. The results revealed that the decrease in temperature resulted in a significant increase in the friction coefficient of the contact pairs, carbon wear, and copper surface roughness. Additionally, the surface oxidation rate was lower at lower temperatures. Moreover, contact resistance did not consistently increase with decreasing temperature, owing to the combined action of the contact area and the oxide film. Compared with temperature, humidity fluctuations at room temperature exerted less influence on the friction coefficient and contact resistance of the contact pairs. Dry environments rendered carbon materials vulnerable to oxidation and cracking, while excessive humidity fostered abrasive wear and arcing. High-current conditions generally degraded the tribological properties of C/Cu contacts. In the absence of current, the friction coefficient was extremely high, and the copper transfer was high. Under excessive current, copper was susceptible to plowing by carbon micro-bumps and abrasive particles, resulting in a decrease in the friction coefficient. The release of lipids from the carbon surface due to temperature elevation weakened the electrical contact performance and increased the occurrence of arc erosion, thereby exacerbating carbon wear.

关键词： temperature/humidity pantograph-catenary system C/Cu wear current-carrying friction sliding electrical contact

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Distribution of modified Circumpolar Deep Water and its threat in Vincennes Bay,east Antarctica

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Journal of Oceanology and Limnology 2024年第5期42卷 1399-1414页

作者： Wenjun YE Lingqiao CHENG Yujiro KITADE Song hu Juncheng ZUO College of Oceanography and Ecological Science Shanghai Ocean UniversityShanghai 201306China Key Laboratory of Marine Ecological Monitoring and Restoration Technologies Ministry of Natural ResourcesShanghai 201306China Department of Ocean Sciences Tokyo University of Marine Science and TechnologyTokyo 108-8477Japan

The Antarctic Bottom Water formation site Vincennes Bay,east Antarctica is experiencing a substantial intrusion of modified Circumpolar Deep Water(mCDW),which may inhibit the formation of Dense Shelf Water(DSW)and drive basal melting of the ice *** on hydrographic data obtained from March to November in 2012,we evaluated the spatial spread of mCDW over the continental shelf region of Vincennes Bay and the associated temporal evolution of water properties,as well as the sea ice formation effect on water column in the coastal *** show that two branches of mCDW occupied the deep layers of the continental shelf,distinguished by the potential density(smaller than 27.8 kg/m^(3) or not)when potential temperatureθ=0.5°C in theθ-salinity *** warmer and less dense branch observed on the east plateau,accessed the eastern ice shelves in the coastal polynya to drive basal melting of ice *** contrast,the other colder and denser branch in the mid-depression reached the western Underwood Ice *** formation was detectable in the coastal polynya during September-November,proving the occurrence of deep *** heat loss and brine rejection during the intensive sea ice formation contributed to the destratification of the water column in the coastal *** was estimated that at least 1.11±0.79 TW heat carried by mCDW into the inner part of the polynya.

关键词： modified circumpolar deep water evolution of water properties coastal polynya ice shelf Vincennes Bay

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中医药类年鉴编纂存在的问题与思考

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史志学刊 2024年第3期 55-64页

作者：胡楠中国中医药出版社有限公司北京100176

中医药类年鉴主要由中医药管理、医疗、教育、科研、产业机构组织编纂,真实记录年度中医药工作各方面情况,特别是新进展、新成就。中医药类年鉴连续公开出版的种类不多,大部分为内部刊印或已停办,且存在人才队伍不稳定、年鉴质量参差不... 详细信息

中医药类年鉴主要由中医药管理、医疗、教育、科研、产业机构组织编纂,真实记录年度中医药工作各方面情况,特别是新进展、新成就。中医药类年鉴连续公开出版的种类不多,大部分为内部刊印或已停办,且存在人才队伍不稳定、年鉴质量参差不齐、信息化水平及年鉴使用率不高、成果转化较少等问题。需要从国家层面重视中医药类年鉴的编纂工作,鼓励全中医药行业编纂年鉴,形成中医药智库,推动中医药事业和产业高质量发展,为建设健康中国、实现中华民族伟大复兴的中国梦贡献力量。

关键词：中医药年鉴编纂数字化中医药智库

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Distribution and Formation Causes of PM_(2.5) and O_(3) Double High Pollution Events in China during 2013–20

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Advances in Atmospheric Sciences 2024年第6期41卷 1235-1250,I0004-I0021页

作者： Zhixuan TONG Yingying YAN Shaofei KONG Jintai LIN nan CHEN Bo Zhu Jing MA Tianliang ZHAO Shihua QI Department of Atmospheric Science School of Environmental SciencesChina University of GeosciencesWuhan 430074China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Research Centre for Complex Air Pollution of hubei Province Wuhan 430074China Laboratory for Climate and Ocean–Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China Eco-Environmental Monitoring Centre of hubei Province Wuhan 430074China Key Laboratory of Atmospheric Chemistry China Meteorological AdministrationBeijing 100081China School of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China

Fine particulate matter(PM_(2.5))and ozone(O_(3))double high pollution(DHP)events have occurred frequently over China in recent years,but their causes are not completely *** this study,the spatiotemporal distribution of DHP events in China during 2013–20 is *** synoptic types affecting DHP events are identified with the Lamb–Jenkinson circulation classification *** meteorological and chemical causes of DHP events controlled by the main synoptic types are further *** show that DHP events(1655 in total for China during 2013–20)mainly occur over the North China Plain,Yangtze River Delta,Pearl River Delta,Sichuan Basin,and Central *** occurrence frequency increases by 5.1%during 2013–15,and then decreases by 56.1%during 2015–*** main circulation types of DHP events are“cyclone”and“anticyclone”,accounting for over 40%of all DHP events over five main polluted regions in China,followed by southerly or easterly flat airflow types,like“southeast”,“southwest”,and“east”.Compared with non-DHP events,DHP events are characterized by static or weak wind,high temperature(20.9℃ versus 23.1℃)and low humidity(70.0%versus 64.9%).The diurnal cycles of meteorological conditions cause PM_(2.5)(0300–1200 LST,Local Standard Time=UTC+8 hours)and O_(3)(1500–2100 LST)to exceed the national standards at different periods of the DHP *** pollutant conversion indices further indicate the rapid secondary conversions during DHP events,and thus the concentrations of NO_(2),SO_(2) and volatile organic compounds decrease by 13.1%,4.7%and 4.4%,*** results of this study can be informative for future decisions on the management of DHP events.

关键词： double high pollution events PM_(2.5) ozone spatiotemporal distribution meteorological causes chemical composition characteristics

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探索儿童主义:理论建构与批判审视

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少年儿童研究 2024年第2期 20-26页

作者：胡南华东师范大学教育学院

儿童主义提供了必要的批判视角,通过将儿童与成年人之间的相互依存关系置于研究和社会关注的中心,重建了更具包容性的学术想象力和社会想象力。本文以童年研究发展为脉络,深入分析儿童主义理论的起源、扩展及其追求的目标,批判性地指出... 详细信息

儿童主义提供了必要的批判视角,通过将儿童与成年人之间的相互依存关系置于研究和社会关注的中心,重建了更具包容性的学术想象力和社会想象力。本文以童年研究发展为脉络,深入分析儿童主义理论的起源、扩展及其追求的目标,批判性地指出儿童主义存在对文化和社会间差异的忽视问题,以及儿童主义的改革仍然受限于成年人主导的社会规范这一先入为主的框架,旨在揭示儿童主义在重新定义儿童研究范式、引领学科发展方向方面的深远影响及其面临的挑战。

关键词：儿童主义童年童年研究理论演变

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TSDSIR:机器人系统中多业务并发的消息数据流调度

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通信学报 2024年第8期45卷 205-220页

作者：丁男冀承慧胡创业许力新疆师范大学计算机科学技术学院新疆乌鲁木齐830054 大连理工大学工业装备智能控制与优化教育部重点实验室辽宁大连116024 字节跳动北京100086

针对机器人云-边-端协同场景中所面临的多业务并发、多模态消息数据混杂等特点,基于机器人操作系统2(ROS2)中消息分发机理分析,提出了面向时间敏感属性的多消息动态调度方法。首先,根据ROS2中多话题消息流并发属性和网络实时状态,定义... 详细信息

针对机器人云-边-端协同场景中所面临的多业务并发、多模态消息数据混杂等特点,基于机器人操作系统2(ROS2)中消息分发机理分析,提出了面向时间敏感属性的多消息动态调度方法。首先,根据ROS2中多话题消息流并发属性和网络实时状态,定义了消息数据优先权、最大传输时间和剩余传输时间等流调度参数,进而对待调度的流队列状态进行实时表征。其次,设计了包含时间优先和优先权优先的混杂切换调度模型,并结合流调度参数给出调度切换规则及理论边界条件。最后,提出了ROS2中面向时间敏感属性的多消息动态调度方法,并在其数据分发服务层中集成应用。仿真实验与实际应用验证表明,所提方法能提升ROS2中多消息流并发传输效率,同时保障高优先级的、具有时间敏感属性的消息数据实时可靠传输。

关键词：机器人操作系统2 数据分发服务时间敏感属性混杂切换多消息流调度

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