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Ocular findings in children with thalassemia major in Eastern Mediterranean

International Journal of Ophthalmology(English edition) 2014年第1期7卷 118-121页

作者： Adnan Aksoy Murat Aslankurt lokman Aslan zlem gül Mesut garipard| Oguz elik Seydi Okumus Murat zdemir gkhan zdemir Department of Ophthalmology KSU Faculty of Medicine Department of Pediatric Haematology KSU Faculty of Medicine Department of Ophthalmology Faculty of MedicineGaziantep University

AIM: To investigate ophthalmologic findings in children with thalassemia major(TM) and compare the findings with healthy controls. ·METHODS: In a cross-sectional study,43 children with thalassemia major from pediatric hematology outpatient clinics from two university hospitals and age/sex matched 47 healthy children were included in the study. After a complete ophthalmic examination,tear function tests including the Schirmer test,fluorescein tear breakup time(BUT),ultrasound pachymetry,and axial length measurement were performed. Obtained data was recorded for statistical analysis and the values of right eyes were compared between groups. ·RESUlTS: The mean best corrected visual acuity was 1.34 ±0.75 in TM and 1.08 ±0.28 in controls. It was found lower than 0.1 logMAR unit in 10(23.2%) children with TM and 2(4.2%) in controls,and the difference was statistically significant(P <0.05). The mean central corneal thickness was 540±26.95 in children with TM and 536.98± 20.45μm in controls(P >0.05). The mean axial length was 22.53±0.50 in TM and 22.57±0.43mm in the control group. The mean Schirmer test score was 19.94±6.91 in TM and 24.22±3.95mm in the control group(P <0.01). The mean BUT score was 9.62 ±1.28 in TM and 9.73 ±0.6s in the control group(P >0.05). ·CONClUSION: In TM,while corneal thickness,axial length,and BUT are close to controls,the Schirmer scores are less than normal. The study revealed that TM may be affected by the tear function and visual acuity.

关键词： thalassemia major ocular findings tear function test central corneal thickness axial length

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Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKgROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

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SYNTHESES AND CHARACTERIZATION OF POlY(IMINOPHENOl)S DERIVED FROM 4-BROMOBENZAlDEHYDE:THERMAl,OPTICAl,ElECTROCHEMICAl AND FlUORESCENT PROPERTIES

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Chinese Journal of Polymer Science 2012年第6期30卷 796-807页

作者： Ismet Kaya Ali Avci Özlem gültekin Canakkale Onsekiz Mart University Faculty of Sciences and ArtsDepartment of Chemistry17020CanakkaleTurkey Celal Bayar University Faculty of Sciences and ArtsDepartment of Chemistry45040ManisaTurkey

Schiff base monomers [2-（4-bromobenzylideneamino）phenol and 2-（4-bromobenzylideneamino）-5-methylphenol] were synthesized by the condensation reaction of 4-bromobenzaldehyde with aromatic aminophenols. Then, the monomers were converted to their polyphenol derivatives by oxidative polycondensation reactions （OP） in an aqueous alkaline medium. The structures of the synthesized compounds were characterized by solubility tests, FT-IR, NMR, Tg-DTA, DSC and SEC techniques. The HOMO-lUMO energy levels and electrochemical （E＇g） and optical （Eg） band gaps were calculated from cyclic voltammetry （CV） and UV-Vis measurements, respectively. Cyclic voltammetry （CV） was used to determine the electrochemical oxidation-reduction characteristics. Optical properties were investigated by UV-Vis and fluorescence analyses. Solid state electrical conductivities were measured on polymer films by four point probe technique using a Keithley 2400 electrometer. The effects of electron-donating （--CH3） group at p-position of --NH2 group in aminophenol on electrochemical and thermal properties were also discussed. Photoluminescence （Pl） properties of the synthesized materials were determined in solution forms using different solvents. Fluorescence measurements were carried out in various concentrated solutions to determine the optimum concentrations to obtain the maximal Pl intensities.

关键词： Schiff base polymers Thermal analysis Fluorescence Cyclic voltammetry Conductivity.

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Cellular and molecular mechanisms in the pathogenesis of liver fibrosis:An update

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World Journal of gastroenterology 2014年第23期20卷 7260-7276页

作者： gülsüm ?zlem Elpek Department of Pathology Akdeniz University Medical School07070 AntalyaTurkey

There have been considerable recent advances towards a better understanding of the complex cellular and molecular network underlying liver *** data indicate that the termination of fibrogenic processes and the restoration of deficient fibrolytic pathways may allow the reversal of advanced fibrosis and even ***,efforts have been made to better clarify the cellular and molecular mechanisms that are involved in liver *** of hepatic stellate cells(HSCs)remains a central event in fibrosis,complemented by other sources of matrix-producing cells,including portal fibroblasts,fibrocytes and bone marrow-derived *** cells converge in a complex interaction with neighboring cells to provoke scarring in response to persistent *** the interaction of different cell types,revealing the effects of cytokines on these cells and characterizing the regulatory mechanisms that control gene expression in activated HSCs will enable the discovery of new therapeutic ***,the characterization of different pathways associated with different etiologies aid in the development of disease-specific *** article outlines recent advances regarding the cellular and molecular mechanisms involved in liver fibrosis that may be translated into future *** pathogenesis of liver fibrosis associated with alcoholic liver disease,non-alcoholic fatty liver disease and viral hepatitis are also discussed to emphasize the various mechanisms involved in liver fibrosis.

关键词： liver liver fibrosis Cirrhosis Fibrogenesis Hepatic stellate cells Myofibroblast Extracellular matrix

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Spatial and seasonal distribution of macroinvertebrates in high altitude reservoir (Beyler Reservoir, Turkey)

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Chinese Journal of Oceanology and limnology 2013年第5期31卷 994-1001页

作者： zlem FINDIK Arts and Sciences Faculty Molecular Biology and Genetic DepartmentNevehir University

A highland reservoir in the West Black Sea region of Turkey which belongs to the Mediterranean climatic zone was *** littoral and profundal zones were sampled from October 2009 to September 2010,to determine taxonomic composition,biodiversity and abundance of benthic invertebrates as well as the seasonal variation of these measures.A total of 35 taxa were identified,of which 12 belong to Chironomidae and 10 to Oligochaeta *** highest diversity and abundance of benthic macroinvertebrates were found at the littoral *** showed significant positive correlations with water temperature and NO_2 and NO_3 concentrations,and negative correlation with dissolved oxygen.

关键词： macrofauna zoobenthos community structure littoral West Black Sea

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Efficacy of Bee Products(Anzer Honey,Pollen and Propolis)in Detection and Healing of Damage Induced by Antidiabetic Drug Vildagliptin/Metformin Hydrochloride in Healthy Human Pancreatic Cells:Cytotoxic,genotoxic and Biochemical Studies

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Current Medical Science 2023年第6期43卷 1173-1182页

作者： ÖzlemÖzdemir ZinetÇöl Ömer Ertürk Department of Internal Medicine Faculty of MedicineOrdu UniversityOrdu52200Turkey Department of Molecular Biology and genetics Faculty of Sciences and LettersOrdu UniversityOrdu52200Turkey

Background and Objective Although drugs are powerful therapeutic agents,they have a range of side *** side effects are sometimes cellular and not clinically ***/metformin hydrochloride is one of the most widely used oral antidiabetic drugs with two active *** this study,we investigated its harmful effects on the metabolic activation system in healthy human pancreatic cells“hTERT-HPNE”,and we aimed to improve these harmful effects by natural *** benefit from the healing effect,we used the unique natural products produced by the bees of the Anzer Plateau in the Eastern Black Sea Region of *** Cytotoxic and genotoxic effects of the drug were investigated by different tests,such as MTT,flow cytometry-apoptosis and comet *** honey,pollen and propolis were analyzed by gas chromatography/mass spectrometry(g/C-MS).A total of 19 compounds were detected,constituting 99.9%of the *** The decrease in cell viability at all drug concentrations was statistically significant compared to the negative control(Plly significant decrease was detected in the apoptosis caused by vildagliptin/metformin hydrochloride with the supplementation of Anzer honey,pollen and propolis in hTERT-HPNE cells(Plusion This study can contribute to other studies testing the healing properties of natural products against the side effects of oral antidiabetics in human *** particular,Anzer honey,pollen and propolis can be used as additional foods to maintain cell viability and improve heal damage and can be evaluated against side effects in other drug studies.

关键词： cell viability hTERT-HPNE Anzer bee products drug side effect diabetes mellitus

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An SPH Framework for Earthquake-Induced liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlógál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNgCs). However, the use of tNgCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNgC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNgCs and compared the various features of these improved silk^(+) tNgCs with the tubes without holes(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNgCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNgCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNgCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNgCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Inflammatory Myofibroblastic Tumor of the liver:A Diagnostic Challenge

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Journal of Clinical and Translational Hepatology 2014年第1期2卷 53-57页

作者： gülsüm (O)zlem Elpek Department of Pathology Akdeniz University Medical School Antalya Turkey

Inflammatory myofibroblastic tumor (IMT) is an uncommon myofibroblastic neoplasm that was formerly included within the broad category of inflammatory pseudotumor (IPT).IMT is rarely encountered in the *** to IMT of other organs,the interchangeable use of the terms IMT and IPT in liver has made the analysis of these lesions *** this review,clinical and pathological features of IMT of the liver are reviewed and the differential diagnosis of IMT is discussed,with emphasis on IPT and the other entities included in this large *** can mimic malignant *** are no known unique diagnostic clinical,laboratory,or radiological *** definitive diagnosis of IMT depends on careful pathological *** histopathological evaluation of hepatic IMT reveals that,the myxoid/vascular pattern is the most frequently observed,followed by,in decreasing frequency,fibrous histiocytomalike pattern and hypocellular fibrous *** IMT of the liver,anaplastic lymphoma kinase (AlK) expression reliably predicts the presence of an AlK gene *** diagnosis of hepatic IMT depends on the dominant histopathological pattern,and the management of the disease is still *** the liver is a distinctive neoplasm of intermediate biological potential,and should be distinguished from the variety of lesions that are included under the broad category of ***,to avoid confusion regarding the true incidence and behavior of hepatic IMT,the term IPT should not be used interchangeably with *** rarity of IMT in liver should not minimize its consideration in the differential diagnosis of liver tumors,especially in patients with tumor markers in normal range.

关键词： Inflammatory myofibroblastic tumor liver Anaplastic lymphoma kinase Inflammatory pseudotumor

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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

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