Cellular and molecular mechanisms in the pathogenesis of liver fibrosis:An update

作     者：Gülsüm ?zlem Elpek 

作者机构：Department of PathologyAkdeniz University Medical School07070 AntalyaTurkey 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第23期

页      面：7260-7276页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Liver Liver fibrosis Cirrhosis Fibrogenesis Hepatic stellate cells Myofibroblast Extracellular matrix 

摘      要：There have been considerable recent advances towards a better understanding of the complex cellular and molecular network underlying liver *** data indicate that the termination of fibrogenic processes and the restoration of deficient fibrolytic pathways may allow the reversal of advanced fibrosis and even ***,efforts have been made to better clarify the cellular and molecular mechanisms that are involved in liver *** of hepatic stellate cells(HSCs)remains a central event in fibrosis,complemented by other sources of matrix-producing cells,including portal fibroblasts,fibrocytes and bone marrow-derived *** cells converge in a complex interaction with neighboring cells to provoke scarring in response to persistent *** the interaction of different cell types,revealing the effects of cytokines on these cells and characterizing the regulatory mechanisms that control gene expression in activated HSCs will enable the discovery of new therapeutic ***,the characterization of different pathways associated with different etiologies aid in the development of disease-specific *** article outlines recent advances regarding the cellular and molecular mechanisms involved in liver fibrosis that may be translated into future *** pathogenesis of liver fibrosis associated with alcoholic liver disease,non-alcoholic fatty liver disease and viral hepatitis are also discussed to emphasize the various mechanisms involved in liver fibrosis.