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Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension

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癌症生物学与医学：英文版 2017年第4期14卷 405-413页

作者： Filiz Kisaayak Collak Ummuhan Demir Seyma Ozkanli Esra Kurum Pinar engin Zerk Molecular Biology and Genetics Department Faculty of Engineering and Natural Sciences Istanbul Medeniyet University Istanbul 34700 Turkey pathology Department Faculty of Medicine Istanbul Medeniyet University Istanbul 34700 Turkey Statistics Department University of California Riverside Riverside CA 92521 USA

Objective:Yes associated protein 1(YAP1)is a member of the Hippo pathway,acting as a transcriptional *** elucidate the role of YAP1 and phosphorylated(p)YAP1 in prostate cancer(PCa)tumorigenesis,we investigated their expression in clinical samples of PCa and cell ***:Fifty-four tumor,adjacent nontumor,and prostate intraepithelial neoplasia(PIN)tissues from patients with PCa after radical prostatectomy were selected from a retrospective cohort and studied using immunohistochemistry(IHC).Protein and m RNA expression levels of YAP1 were evaluated by Western blot analysis and quantitative real-time reverse transcription PCR,respectively,in cancer cell *** available gene expression datasets were downloaded to analyze YAP1 m RNA and protein levels in PCa tissue ***:IHC analysis of PCa tissues revealed that YAP1 staining intensities were moderate to weak in the nucleus and cytoplasm of tumor cells,whereas adjacent normal epithelia showed strong *** observed that benign prostates were characterized by higher expression levels of both nuclear(P=0.004)and cytosolic(P=0.005)YAP1.p YAP1 staining was weak in the cytoplasm and absent in the nucleus of all the tissues ***1 expression was an indicator of extraprostatic extension(EPE).The level of YAP1 was negatively correlated with the level of the androgen receptor(AR)in The Cancer Genome Atlas dataset and Western blot analysis of cell ***:Our study suggested that YAP1 expression is heterogeneous in PCa tissue samples;therefore,YAP1 might play different roles in different aspects of PCa *** might involve AR–YAP1 interplay in PCa.

关键词： YAP1 pYAP1 PCa

Chemical Effect on K Shell X-ray Fluorescence Parameters and Radiative Auger Ratios of Co, Ni, Cu, and Zn Complexes

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Chinese Journal of Chemical Physics 2010年第2期23卷 138-144,I0001页

作者： Erhan Cengiz Zekeriya Biyiklioglu Nuray Kup Ayhkcl Volkan Aylikci Gokhan Apaydin engin Tirasglu Halit Kantekin 黑海技术大学理学院物理系特拉布宗61080土耳其黑海技术大学理学院化学系特拉布宗61080土耳其

The production cross-sections, intensity ratios, and radiative Auger intensity ratios of Co, Ni, Cu, and Zn elements in different complexes were measured. The chemical effects on the K shell fluorescence parameters and the radiative Auger intensity ratios of these elements were investigated and the changes in these parameters were interpreted according to the charge transfer process. The samples were excited by 59.5 keV γ-rays from a ^241Am annular radioactive source. K X-rays emitted by samples were counted by an Ultra-LEGe detector with a resolution of 150 eV at 5.9 keV.

关键词： Charge transfer Cross-section Radiative Auger intensity ratio Ultra-LEGe detector Chemical effect

Corneal matrix repair therapy with the regenerating agentin neurotrophic persistent epithelial defects

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1935-1939页

作者： Canan Asli Utine Ceren engin Durmaz Nilufer Kocak Department of Ophthalmology Faculty of MedicineDokuz Eylaul UniversiltyIzmir 35340Turkey

Citation： Utine CA, engin Durmaz C, Koqak N. Corneal matrix repair therapy with the regenerating agent in neurotrophic persistent epithelial defects, lntJOphthalmo12017;10（12）：1935-1939

关键词： PED Corneal matrix repair therapy with the regenerating agent in neurotrophic persistent epithelial defects

Chronic constipation:Facilitator factor for development of varicocele

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World Journal of Gastroenterology 2011年第21期17卷 2641-2645页

作者： Guldem Kilciler Ahmet Ali Sancaktutar Ali Avcl Mete Kilciler engin Kaya Murat Dayanc Department of Gastroenterology Gulhane Military Medical Academy Department of Urology Gulhane Military Medical Academy

AIM:To evaluate the possible relationship between varicocele and chronic ***:Between April 2009 and May 2010,a total of 135 patients with varicocele or constipation and 120 healthy controls were *** were divided into two *** both groups detailed medical history was taken and all patients were examined physically by the same urologist and *** of them were evaluated by color Doppler *** patients with constipation,except for the healthy controls of the second group,underwent a colonoscopy to identify the etiology of the *** the first group,we determined the rate of chronic constipation in patients with varicocele and in the second group,the rate of varicocele in patients with chronic *** both groups,the rate of the disease was compared with age-matched healthy *** the second group,the results of colonoscopies in the patients with chronic constipations were also ***:In the first group,mean age of the study and control groups were 22.9 ± 4.47 and 21.8 ± 7.21 years,respectively(P < 0.05).In the second group,mean age of the study and control groups were 52.8 ± 33.3 and 51.7 ± 54.3 years,respectively(P < 0.05).In the first group,chronic constipation was observed in 8 of the 69 patients with varicocele(11.6%) and 3 out of 60 in healthy controls(5%),*** this regard,there was no statistical significance between varicocele patients and the healthy control(P = 0.37).In the second group,varicocele was observed in 16 of the 66 patients with chronic constipation(24.24%) and 12 out of 60 in healthy controls(20%) ***,there was no statistical significance between chronic constipation and healthy controls(P = 0.72).Internal/external hemorrhoids were detected in 4 of the 16 patients with chronic constipation and varicocele,in the second *** the remaining 50 patients with chronic constipation 9 had internal/external *** this

关键词： Varicocele Chronic constipation Hemorrhoid Intra-abdominal pressure Relationship

Speech and language therapy for aphasia following subacute stroke

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Neural Regeneration Research 2016年第10期11卷 1591-1594页

作者： engin Koyuncu Pinar Cam Nermin Altinok Duygu Ekinci Calli Tuba Yarbay Duman Nese Ozgirgin Department of Physical Medicine and Rehabilitation Ankara Physical Medicine and Rehabilitation Training and Research Hospital Ankara Turkey Department of Psychology Ankara Physical Medicine and Rehabilitation Training and Research Hospital Ankara Turkey Department of Linguistics Amsterdam Center for Language and Communication Amsterdam Brain and Cognition Center University ofAmsterdam Amsterdam The Netherlands

The aim of this study was to investigate the time window, duration and intensity of optimal speech and language therapy applied to aphasic patients with subacute stroke in our hospital. The study consisted of 33 patients being hospitalized for stroke rehabilitation in our hospital with first stroke but without previous history of speech and language therapy. Sixteen sessions of impairment-based speech and language therapy were applied to the patients, 30-60 minutes per day, 2 days a week, for 8 successive weeks. Aphasia assess- ment in stroke patients was performed with Giilhane Aphasia Test-2 before and after treatment. Compared with before treatment, fluency of speech, listening comprehension, reading comprehension, oral motor evaluation, automatic speech, repetition and naming were improved after treatment. This suggests that 16 seesions of speech and language therapy, 30-60 minutes per day, 2 days a week, for 8 successive weeks, are effective in the treatment of aphasic patients with subacute stroke.

关键词： nerve regeneration stroke aphasia speech and language therapy disability rehabilitation GiilhaneAphasia Test-2 neural regeneration

Effects of terlipressin on systolic pulmonary artery pressure of patients with liver cirrhosis: An echocardiographic assessment

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World Journal of Gastroenterology 2004年第15期10卷 2278-2280页

作者： engin Altintas Necdet Akkus Ramazan Gen M.Rami Helvaci Orhan Sezgin Dilek Oguz Division of Gastroenterology Mersin UniversitySchool of MedicineMersinTurkey Cardioiogy Department Mersin UniversitySchool of MedicineMersinTurkey Internal Medicine Department Mersin UniversitySchool of MedicineMersinTurkey Gastroenterology

AIM:Portopulmonary hypertension is a serious complication of chronic liver *** aim was to search into the effect of terlipressin on systolic pulmonary artery pressure among cirrhotic patients. METHODS:Twelve patients(6 males and 6 females)with liver cirrhosis were recruited in the *** blood gas samples were obtained in sitting position at *** enhanced echocardiography and measurements of systolic pulmonary artery pressure were performed before and after the intravenous injection of 2 mg terlipressin. RESULTS:Of 12 patients studied,the contrast enhanced echocardiography was positive in 5,and the positive findings in contrast enhanced echocardiography were reversed to normal in two after terlipressin *** mean systolic pulmonary artery pressure was 25.5±3.6 mmHg before terlipressin injection,and was 22.5+2.5 mmHg after terlipressin(P=0.003).The systolic pulmonary artery pressure was above 25 mmHg in seven of these 12 patients. After the terlipressin injection,systolic pulmonary artery pressure was<25 mmHg in four of these cases(58.3% vs 25%,P=0.04). CONCLUSION:Terlipressin can decrease the systolic pulmonary artery pressure in patients with liver cirrhosis.

关键词： Blood Pressure Adult Antihypertensive Agents Echocardiography Female Humans Liver Cirrhosis Lypressin derivatives Male Middle Aged Pulmonary Artery

Reactive oxygen species and chemokines: Are they elevated in the esophageal mucosa of children with gastroesophageal reflux disease?

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World Journal of Gastroenterology 2008年第20期14卷 3218-3223页

作者： engin Tutar Deniz Ertem Goksenin Unluguzel Sevda Tanrikulu Goncagul Haklar Cigdem Celikel Evin Ademoglu Ender Pehlivanoglu Division of Pediatric Gastroenterology Hepatology and Nutrition Marmara University School of Medicine Altunizade stanbul 81190 Turkey Department of Biochemistry Marmara University School of Medicine Altunizade stanbul 81190 Turkey Department of Biochemistry Istanbul University Istanbul Faculty of Medicine apa stanbul 34390 Turkey Department of Pathology Marmara University School of Medicine Altunizade stanbul 81190 Turkey

AIM: To determine the role of inflammatory cytokines and reactive oxygen species (ROS) in childhood reflux esophagitis. METHODS: A total of 59 subjects who had complaints suggesting GERD underwent esophagogastroduoden oscopy. Endoscopic and histopathologic diagnosis of reflux esophagitis was established by Savary-Miller and Vandenplas grading systems, respectively. Esophageal biopsy specimens were taken from the esophagus 20% proximal above the esophagogastric junction for conventional histopathological examination and the measurements of ROS and cytokine levels. ROS were measured by chemiluminescence, whereas IL-8 and MCP-1 levels were determined with quantitative immunometric ELISA on esophageal tissue. Esophagealtissue ROS, IL-8 and MCP-1 levels were compared among groups with and without endoscopic/histo- pathologic esophagitis. RESULTS: Of 59 patients 28 (47.5%) had normal esophagus whereas 31 (52.5%) had endoscopic esophagitis. In histopathological evaluation, almost 73% of the cases had mild and 6.8% had moderate degree of esophagitis. When ROS and chemokine levels were compared among groups with and without endoscopic esophagitis, statistical difference could not be found between patients with and without esophagitis. Although the levels of ROS, IL-8 and MCP-1 were found to be higher in the group with histopathological reflux esophagitis, this difference was not statistically significant. CONCLUSION: These results suggest that the grade of esophagitis is usually mild or moderate during childhood and factors apart from ROS, IL-8 and MCP-1 may be involved in the pathogenesis of reflux esophagitis in children.

关键词： Gastroesophageal reflux disease Refluxesophagitis Reactive oxygen species Interleukine-8 Monocyte chemoattractant protein-1

Is hemodialysis a reason for unresponsiveness to hepatitis B vaccine? Hepatitis B virus and dialysis therapy

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World Journal of Hepatology 2015年第5期7卷 761-768页

作者： Dede Sit Bennur Esen Ahmet engin Atay Hasan Kayabasi Department of Internal Medicine and Nephrology Bagcilar Education and Research Hospital

Impaired renal function is associated with a high risk of chronicity of hepatitis B virus(HBV) *** on hemodialysis(HD) or peritoneal dialysis are at an increased risk of viral transmission due to frequent necessity of blood product transfer as well as use of contaminated dialysate or dialysis ***,health professionals may cause viral spread via contaminated hands and carelessness against hygiene *** frequency of chronic HBV infection may be as high as 80% in patients on renal replacement *** is because HBV vaccination is essential to eliminate chronic HBV ***,response rates of HD patients to HBV vaccination vary between 10%-50%.Dialysis adequacy and early vaccination before the onset of dialysis therapy seem to be major determinants of high seroconversion *** age,male gender,duration of dialysis therapy and nutritional status are other well-known factors associated with seroconversion *** are controversial reports regarding the role of the presence of diabetes mellitus,HCV positivity,erythropoietin resistance,hyperparathyroidism,and vitamin D *** role of genetic alteration in the functions or production of cytokines still needs to be elucidated.

关键词： Hepatitis B virus Vaccine Hemodialysis Response End stage renal disease

Effect of interferon and ribavirin combined with amantadine in interferon and ribavirin non-responder patients with chronic hepatitis C (genotype 1)

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World Journal of Gastroenterology 2005年第4期11卷 580-583页

作者： Dilek Oguz Bahattin Cicek Levent Filik Bulent Odemis Mesut Kilic engin Altintas Neslihan Zengin Emin Altiparmak Turkiye Yuksek Ihtisas Hospital Gastroenterology Clinic Mersin University Department of Gastroenterology Turkiye Yuksek Ihtisas Hospital Department of Pathology Turkiye Yuksek Ihtisas Hospital Gastroenterology Clinic

AIM: To evaluate the efficacy of amantadine plus interferonalpha and ribavirin in non-responder patients with chronic hepatitis ***: Twenty-six non-responder patients received the regimen of IFN-α-2a at a dose of 6 million units three times a week, 1 000-1 200 mg of ribavirin daily, and 200 mg of amantadine daily in divided doses over 48 wk. After the end of treatment, at the 72nd wk, a sustained viral response rate was ***: An early (after 12 wk of therapy) response was seen in 34.6% (9/26) of patients. Response rate at the 24th wk was 42.3% (11/26). End of treatment response (ETR) was 53.8% (14/26). Sustained viral response (SVR) was 42.3% (11/26). There was a statistically significant difference between 0 and 12 wk (P = 0.04), 0 and 24 wk (P = 0.01), 0 and 48 wk (P = 0.00), and 0 and 72 wk (P = 0.001). No patient had severe adverse effects during the ***: Combination regimen of interferon-α,ribavirin and amantadine can enhance sustained viral response on IFN-α and ribavirin non-responder patients with HCV. Triple therapy with amantadine should be evaluated in further studies.

关键词： Chronic hepatitis C IFN-α-2a Ribavirin