Is hemodialysis a reason for unresponsiveness to hepatitis B vaccine? Hepatitis B virus and dialysis therapy
Is hemodialysis a reason for unresponsiveness to hepatitis B vaccine? Hepatitis B virus and dialysis therapy作者机构：Department of Internal Medicine and NephrologyBagcilar Education and Research Hospital
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2015年第7卷第5期
页 面：761-768页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Hepatitis B virus Vaccine Hemodialysis Response End stage renal disease
摘 要：Impaired renal function is associated with a high risk of chronicity of hepatitis B virus(HBV) *** on hemodialysis(HD) or peritoneal dialysis are at an increased risk of viral transmission due to frequent necessity of blood product transfer as well as use of contaminated dialysate or dialysis ***,health professionals may cause viral spread via contaminated hands and carelessness against hygiene *** frequency of chronic HBV infection may be as high as 80% in patients on renal replacement *** is because HBV vaccination is essential to eliminate chronic HBV ***,response rates of HD patients to HBV vaccination vary between 10%-50%.Dialysis adequacy and early vaccination before the onset of dialysis therapy seem to be major determinants of high seroconversion *** age,male gender,duration of dialysis therapy and nutritional status are other well-known factors associated with seroconversion *** are controversial reports regarding the role of the presence of diabetes mellitus,HCV positivity,erythropoietin resistance,hyperparathyroidism,and vitamin D *** role of genetic alteration in the functions or production of cytokines still needs to be elucidated.
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