Effects of terlipressin on systolic pulmonary artery pressure of patients with liver cirrhosis: An echocardiographic assessment

作     者：Engin Altintas Necdet Akkus Ramazan Gen M.Rami Helvaci Orhan Sezgin Dilek Oguz 

作者机构：Division of GastroenterologyMersin UniversitySchool of MedicineMersinTurkey Cardioiogy DepartmentMersin UniversitySchool of MedicineMersinTurkey Internal Medicine DepartmentMersin UniversitySchool of MedicineMersinTurkey Gastroenterology 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第15期

页      面：2278-2280页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Blood Pressure Adult Antihypertensive Agents Echocardiography Female Humans Liver Cirrhosis Lypressin derivatives Male Middle Aged Pulmonary Artery 

摘      要：AIM:Portopulmonary hypertension is a serious complication of chronic liver *** aim was to search into the effect of terlipressin on systolic pulmonary artery pressure among cirrhotic patients. METHODS:Twelve patients(6 males and 6 females)with liver cirrhosis were recruited in the *** blood gas samples were obtained in sitting position at *** enhanced echocardiography and measurements of systolic pulmonary artery pressure were performed before and after the intravenous injection of 2 mg terlipressin. RESULTS:Of 12 patients studied,the contrast enhanced echocardiography was positive in 5,and the positive findings in contrast enhanced echocardiography were reversed to normal in two after terlipressin *** mean systolic pulmonary artery pressure was 25.5±3.6 mmHg before terlipressin injection,and was 22.5+2.5 mmHg after terlipressin(P=0.003).The systolic pulmonary artery pressure was above 25 mmHg in seven of these 12 patients. After the terlipressin injection,systolic pulmonary artery pressure was25 mmHg in four of these cases(58.3% vs 25%,P=0.04). CONCLUSION:Terlipressin can decrease the systolic pulmonary artery pressure in patients with liver cirrhosis.