检索结果-南通市图书馆

CellBio 2016年第2期5卷 15-25页

作者： Felipe Rodrigues Annelise Pezzi álvaro laureano Vanessa Valim Bruna Zambonato Alice Dahmer Letícia Baggio Filipe Sehn Ianaê Wilke Maria Aparecida L. da Silva Bruna Amorin Cellular Therapy Center Hospital de Clínicas de Porto Alegre Porto Alegre Brazil Laboratory of Cell Culture and Molecular Analysis of Human Cells Hospital de Clínicas de Porto Alegre Porto Alegre Brazil Laboratory of Cell Culture and Molecular Analysis of Human Cells Hospital de Clínicas de Porto Alegre Porto Alegre Brazil Post-graduation in Medicine: Medical Sciences Federal University of Rio Grande do Sul Porto Alegre Brazil

Background: Mesenchymal stromal cells (MSC) are being tested for the treatment of immune diseases. MSC are present in several adult tissues which milieu may influence MSC behavior particularly under inflammatory conditions. Additionally, culture conditions also can modify cell function or state of activation. Methods: To address the influence of the MSC source on its characteristics, we studied a xenofree, platelet lysate supplemented MSC from dental pulp, adipose tissue and bone marrow, co-cultured with isolated T cells and PBMC subset, and studied the effect of culture animal or human supplements immunomodulatory effect. Results: All three sources were efficient in inhibiting T cells. Among all MSC sources, as also described by others, adipose MSC was capable to significantly induce Treg phenotype and decrease T CD8+. Furthermore, comparing fetal bovine serum and platelet lysate, results demonstrate that platelet lysate alone is capable to induce immunomodulatory phenotype. Additional studies have to be made to elucidate the PL immunomodulatory effect.

关键词： Mesenchymal Stromal Cells Dental Pulp Adipose Tissue Bone Marrow T Cells Immunomodulatory Effect

Computing the topology of an arrangement of implicitly defined real algebraic plane curves~§

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1685-1693页

作者： Jorge CARAVANTES laureano GONZALEZ-VEGA Department of Mathematics Statistics and ComputationUniversity of CantabriaSantander39005CantabriaSpain

We introduce a new algebraic approach dealing with the problem of computing the topology of an arrangement of a finite set of real algebraic plane curves presented implicitly. The main achievement of the presented method is a complete avoidance of irrational numbers that appear when using the sweeping method in the classical way for solving the problem at hand. Therefore, it is worth mentioning that the efficiency of the proposed method is only assured for low-degree curves.

关键词：拓扑计算平面曲线扫描代数

Analysis of tumor-draining vein secretome: A direct access to tumor-derived extracellular vesicles in surgical lung cancer patients

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2023年第5期47卷 951-957页

作者： YANGYI HE DAVID SANCHEZ-LORENTE MELISSA ACOSTA-PLASENCIA MARC BOADA ANGELA GUIRAO RAMON MMARRADES laureano MOLINS ALFONS NAVARRO Molecular Oncology and Embryology Laboratory Department of Surgery and Surgical SpecializationsHuman Anatomy UnitFaculty of Medicine and Health SciencesUniversitat de Barcelona(UB)Barcelona08036Spain School of Basic Medical Sciences Chengdu UniversityChengdu610106China Department of Thoracic Surgery Hospital Clínic de BarcelonaUniversitat de Barcelona(UB)Barcelona08036Spain Thoracic Oncology Unit Hospital ClinicBarcelona08036Spain Institut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS) Barcelona08036Spain Department of Pneumology Institut Clínic Respiratori(ICR)Hospital Clínic de BarcelonaUniversitat de Barcelona(UB)Barcelona08036Spain Centro de Investigación Biomédica en Red de Enfermedades Respiratorias(CIBERES) Instituto de Salud Carlos IIIMadrid28029Spain

Tumor-secreted extracellular vesicles(EVs)participate in the metastasis process through different mechanisms,including the preparation of the pre-metastatic niche to grant circulating tumor cells(CTCs)implantation and *** study of the metastasis process through the analysis of CTCs and tumor-derived EVs is difficult because of the dilution grade of these elements in peripheral *** early-stage lung cancer patients,the tumor-secreted products are even more *** attractive strategy in surgical lung cancer patients is to purify them from a pulmonary tumor-draining vein where they are *** information obtained from the analysis of EVs and CTCs purified from this source could give more accurate information about tumor biology and could be an important source of biomarkers to identify patients at high risk of relapse after curative surgery.

关键词： Lung cancer Liquid biopsy Tumor-draining vein Extracellular vesicles Exosomes

Intelligent Interfaces: Pedagogical Agents and Virtual Humans

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Intelligence Science 2022年第3期12卷 57-78页

作者： Ana Lilia laureano-Cruces Lourdes Sánchez-Guerrero Javier Ramírez-Rodríguez Emiliano Ramírez-laureano Departamento de Sistemas Universidad Autónoma Metropolitana Mexico City México Posgrado en Diseñ o y Visualización de la Información Universidad Autónoma Metropolitana Mexico City México ESCENA Escuela de Animación y Arte Digital Mexico City México

Little by little, we are entering the new era, intelligent interfaces are absorbing us more and more every day, and artificial intelligence makes its presence in a stealthy way. Virtual humans that represent an evolution of autonomous virtual agents;they are computer programs and in the future capable of carrying out different activities in certain environments. They will give the illusion of being human;they will have a body, and they will be immersed in an environment. They will have a set of senses that will allow them: 1) Sensations and therefore associated expressions;2) Communication;3) Learning;4) Remembering events, among others. By integrating the above, they will have a personality and autonomy, so they will be able to plan with respect to objectives;allowing them to decide and take actions with their body, in other words, they will count on awareness. The applications will be focused on environments that they will inhabit, or as interfaces that will interact with other systems. The application domains will be multiple;one of them being education. This article shows the design of OANNA like an avatar with the role of pedagogical agent. It was modeled as an affective-cognitive structure related to the teaching-learning process linked to a pedagogical agent that represents the interface of an artilect. OANNA, has the necessary animations for intervention within the teaching-learning process.

关键词： Intelligent Interfaces Expert Systems Applied to Education Autonomous Virtual Agents Pedagogical Agents Avatar Virtual Humans Operational Strategies Cognitive Strategies Affective-Cognitive Structure

Different maternal investment strategies for male and female calves in a polygynous mammal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2019年第3期65卷 269-277页

作者： Francisco CEACERO Martina KOMARKOVA Andres J.GARCIA laureano GALLEGO Department of Animal Science and Food Processing Faculty of Tropical AgriSciencesCzech University of Life Sciences Kamycka 12916500 Praha 6-Suchdol Czech Republic Department of Ethology Institute of Animal Science Pratelstvi 815 10401 Praha - Uhnneves Czech Republic Instituto de Investigacion en Recursos Cinegeticos (IREC) Consejo Superior de Investigaciones Cientificas-Universidad de Castilla-La Mancha-Junta de Comunidades de Castilla-La Mancha (CSIC-UCLM-JCCM) Ronda de Toledo s/n 13071 Ciudad RealSpain Seccion de Recursos Cinegeticos y Ganaderos Instituto de Desarrollo Regional (IDR)02071 AlbaceteSpain Departamento de Ciencia y Tecnologia Agroforestal y Genetica ETSIAM Universidad de Castilla-La Mancha(UCLM)02071 AlbaceteSpain

Mater nal effects occur whe n the phe no type of the mother in flue nces that of the young to the detriment of her survival, growth or fitn ess. The in vestment of the mother can be affected by mater nal body condition and/or experience. Trivers-Willard Hypothesis (TWH) and Local Resource Competition Hypothesis (LRCH) are the main hypotheses used to explain bias in birth sex-ratios in mammals, as well as for sex-biased maternal investment. Both hypotheses suggest that a different amount of investment must be expected according to the sex of the young. However, recent studies suggest that these differences are not in quantity but in the strategies: mechanisms and objectives may differ for each sex. We studied how maternal characteristics (age, body mass, body condition, and domi nance status) influence re leva nt aspects of the birth and early growth of the calf (birth date, birth body mass, body mass at weaning, and body condition at weaning) separately for each sex;and how that investment is mediated by milk production and composition (lactose, fat, and protein). One hundred eighty-eight newborns from 75 captive red deer hinds aged from 2 to 19 years were analyzed. The main differential investment observed was related to birth date: when producing a female, hinds give birth earlier in the season only if they have a good body condition;however, when gestating a male it is the older hinds those which deliver earlier. Subsequently, milk production and composition are correlated with birth body mass in female calves, but to weaning body mass in males. Thus, only hind body mass affects the weaning body mass of female calves, compared with age and hind body mass in males. These results suggest that while TWH fits the maternal investment strategy found for male calves, it is LRCH which correlates with the maternal investment patterns observed for females.

关键词： birth date body condition local resources competition hypothesis milk production sex-ratio Trivers-Willard hypothesis

Exocrine drainage in pancreas transplantation:Complications and management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2020年第12期10卷 392-403页

作者： Joana Ferrer-Fàbrega laureano Fernández-Cruz HepatoBiliaryPancreatic Surgery and Liver and Pancreas Transplantation Department ICMDMHospital Clinic BarcelonaUniversity of BarcelonaBarcelona Clinic Liver Cancer GroupAugust Pi i Sunyer Biomedical Research InstituteBarcelona 08036BarcelonaSpain Department of Surgery ICMDMHospital Clinic BarcelonaBarcelona 08036BarcelonaSpain

The aim of this minireview is to compare various pancreas transplantation exocrine drainage techniques i.e.,bladder vs *** techniques have different difficulties and *** comparisons have been made in the literature between exocrine drainage techniques throughout the history of pancreas transplantation,detailing complications and their impact on graft and patient *** emphasis has been made on the early postoperative management of these complications and the related surgical infections and their *** light of the results,a number of bladder-drained pancreas grafts required conversion to enteric *** a result of technical improvements,outcomes of the varied enteric exocrine drainage techniques(duodenojejunostomy,duodenoduodenostomy or gastric drainage)have also been discussed i.e.,assessing specific risks vs *** exocrine secretions can be drained to the urinary or intestinal *** the late 1990s the bladder drainage technique was used in the majority of transplant centers due to ease of monitoring urine amylase and lipase levels for evaluation of possible ***,bladder drainage was associated at that time with fewer surgical complications,which in contrast to enteric drainage,could be managed with conservative ***,the most commonly used technique for proper driving of exocrine pancreatic secretions is enteric drainage due to the high rate of urological and metabolic complications associated with bladder *** note,10%to 40%of bladder-drained pancreata eventually required enteric conversion at no detriment to overall graft *** surgical techniques were originally described using the small bowel for enteric anastomosis with Roux-en-Y loop or a direct side-to-side *** the improvements in surgery,enteric drainage complication rates ranging from 2%-20%have been *** depends on the presence of any associated complicati

关键词： Graft survival Patient survival Anastomotic leak Morbidity Infection Surgery

A New Model for Spreading Malware over SMS Using Network Automata

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications and Network 2023年第4期15卷 120-143页

作者： Erick Iván Medina-Salas Ana Lilia laureano-Cruces Ma. Elena Lárraga-Ramírez Posgrado en Ciencia e Ingeniería de la Computación UNAM México City México Departamento de Sistemas UAM-A México City México Laboratoire Informatique d’Avignon Avignon France Instituto de Ingeniería UNAM México City México

By the year 2026, it is estimated that the number of smartphone users in Mexico will be approximately 118.1 million. Each smartphone has the functionality of sending and receiving SMS (Short Message Service) messages, which pose a significant threat to all users, as it makes any device vulnerable to a malware attack. In particular, worm-type malware takes advantage of this means of communication in order to spread. Studying the dynamics of malware propagation can help understand and prevent massive contagion between mobile devices. In this work, a model based on Network Automata and compartmental epidemiological models is presented, aiming to simulate, analyze and study the spread of worm-like malware through sending SMS on smartphones.

关键词： Cellular Automaton Malware Spread Complex Systems Network Automaton

The Ways of Thinking in a Sample of the Student Community of the Subjects of Structured Programming and Numerical Methods in Engineering of the UAM-Azcapotzalco within the Emerging Remote Teaching Project (PEER)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Intelligence Science 2022年第3期12卷 39-56页

作者： Lourdes Sánchez-Guerrero Ana Lilia laureano-Cruces Martha Mora-Torres Javier Ramírez-Rodríguez Departamento de Sistemas Universidad Autónoma Metropolitana-Azcapotzalco Mexico City Mexico Posgrado en Diseñ o y Visualización de la Información Universidad Autónoma Metropolitana-Azcapotzalco Mexico City Mexico

Due to the pandemic that is currently being experienced worldwide, educational institutions (HEIs) have had to reinvent and innovate the mode of teaching, in order to continue the process of training students at all educational levels. Higher education has not been immune to this situation, the institutions of this educational level face various challenges in remote teaching: one of them, perhaps the most important, was to answer the question: How to get the student to continue their undergraduate studies remotely? In this sense, it was necessary, on the part of the students and the teachers, a preparation to go from the face-to-face to the virtual mode. This paper addresses the specific case of the analysis of the teaching-learning process of the Teaching-Learning Unit (UEA for its acronym in Spanish) of Structured Programming and Numerical Methods for Engineering at the undergraduate level, at the Universidad Autónoma Metropolitana, Unidad Azcapotzalco (UAM-A) and its relation to the student’s way of thinking. Likewise, the analysis will be carried out if the way of thinking of the students of the sample influences their academic performance when studying the subject of Structured Programming and Numerical Methods for Engineering.

关键词： Intelligent Teaching Systems Emerging Remote Teaching Project (PEER) Way of Thinking Cognition Motivation and the Locus of Control

Free amino acid content in trunk,branches and branchlets of Araucaria angustifolia(Araucariaceae)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2018年第6期29卷 1489-1496页

作者： Crizane Hackbarth Patricia Soffiatti Fla′vio Zanette Eny Iochevet Segal Floh Amanda Ferreira Macedo Henrique Aparecido laureano Departamento de Fitotecnia e Fitossanitarismo Federal University of Parana(UFPR)Rua dos Funcionarios1540JuveveCuritibaPR 81531-990Brazil Departamento de Botanica Federal University of Parana(UFPR)Av.Cel.Francisco H.dos Santos100Jardim das AmericasCuritibaPR 81531-980Brazil Instituto de Biociencias University of Sao PauloRua do Matao277Sao PauloSP 05508-090Brazil Departamento de Estatstica Federal University of Parana(UFPR)Av.Cel.Francisco H.dos Santos100Jardim das AmericasCuritibaPR 81531-980Brazil

Araucaria angustifolia(Bertol.) O. Kuntze exhibits dimorphism in its stem structure, where the trunk is orthotropic and branches and branchlets(primary and secondary branches) are plagiotropic. These stems exhibit different behavior when used for vegetative propagation,and only segments of trunk can form a complete plant. The physiological and biochemical mechanisms that characterize these stems are still little known. The aim of this study was to describe the free amino acid profiles in trunks,branches, and branchlets of A. angustifolia. Segments of 5 cm in length were excised from young individuals below the stem apex. The needles were removed and samples were frozen and lyophilized. The determinations were made by high-performance liquid chromatography, and the results were expressed as lg/g fresh weight(FW). The trunks and branches had the highest content of total amino acids, which were 112.23 ± 20.57 lg/g FW and 111.97 ± 27.78 lg/g FW, respectively. The amino acids—glutamine, aspartate and c-aminobutyric acid and tyrosine—were noticeably higher in the three types of *** the trunk, a higher amount of asparagine and tryptophan,was also detected. Glutamic acid and glutamine were found in higher quantities in the branches. The branchlets had very low total amino acid content (30.79 ± 4.19 lg/g FW), wherein asparagine is the only amino acid not detected. Thus, it was observed that the profile of the free amino acid differs among trunks, branches, and branchlets in A. angustifolia, indicating that they perform different functions.

关键词： Brazilian pine Physiological mechanisms Stem’s dimorphism Free amino acids

Cysteine and Cysteine-Related SignalingPathways in Arabidopsis thaliana

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2014年第2期7卷 264-276页

作者： Luis C. Romero M. Ángeles Aroca Ana M. laureano-Marín Inmaculada Moreno Irene García Cecilia Gotor Instituto de Bioquímica Vegetal y Fotosíntesis Consejo Superior de Investigaciones Científicas and Universidad de Sevilla Avenida Américo Vespucio 49 41092 Sevilla Spain

Cysteine occupies a central position in plant metabolism because it is a reduced sulfur donor moleculeinvolved in the synthesis of essential biomolecules and defense compounds. Moreover, cysteine per se and its deriva-tive molecules play roles in the redox signaling of processes occurring in various cellular compartments. Cysteine issynthesized during the sulfate assimilation pathway via the incorporation of sulfide to O-acetylserine, catalyzed byO-acetylserine（thiol）lyase （OASTL）. Plant cells contain OASTLs in the mitochondria, chloroplasts, and cytosol, resultingin a complex array of isoforms and subcellular cysteine pools, in recent years, significant progress has been made inArabidopsis, in determining the specific roles of the OASTLs and the metabolites produced by them. Thus, the dis-covery of novel enzymatic activities of the less-abundant, like DES1 with L-cysteine desulfhydrase activity and SCSwith S-sulfocysteine synthase activity, has provided new perspectives on their roles, besides their metabolic ***, the research has been demonstrated that cytosolic sulfide and chloroplastic S-sulfocysteine act as signalingmolecules regulating autophagy and protecting the photosystems, respectively. In the cytosol, cysteine plays an essentialrole in plant immunity; in the mitochondria, this molecule plays a central role in the detoxification of cyanide, which isessential for root hair development and plant responses to pathogens.

关键词： β-cyanoalanine synthase cysteine desulfhydrase cyanide O-acetylserine(thiol)lyase plant development plant immunity redox signaling S-sulfocysteine synthase stress sulfide