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Pharmacologically inhibiting GluR2.internalization alleviates neuropathic pain

Neuroscience Bulletin 2015年第5期31卷 611-616页

作者： Tao-Yan Liu yong Cheng Xiao-Yan Qin Long-Chuan yu Beijing Engineering Research Center of Food Environment and Health Minzu University of China College of Life and Environmental Sciences Minzu University of China Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology College of Life Sciences Peking University Cellular Neurobiology Section Program on Developmental Neuroscience Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health

Neuropathic pain is of serious clinical concern and only about half of patients achieve partial relief with currently-available treatments,so it is critical to find new drugs for this ***,the cellsurface trafficking of pain-related receptors has been suggested as an important mechanism underlying persistent neuropathic ***,we used the short peptide GluA_（2.3y）,which specifically inhibits the GluA2.dependent endocytosis of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors,and tested its anti-nociceptive effect in the periaqueductal grey（PAG） of intact rats and rats with neuropathic ***-PAG injection of 0.15,1.5,7.5,and 15 pmol of GluA_（2.3y） induced dose-dependent increases in hindpaw withdrawal latencies to noxious thermal and mechanical stimuli in intact rats,suggesting that GluA2.cell-surface trafficking in the PAG is involved in pain ***,GluA_（2.3y） had much stronger anti-nociceptive effects in rats with neuropathic pain induced by sciatic nerve ***,the intra-PAG injection of 15 pmol GluA_（2.3y） had an analgesic effect similar to 10 ug（35nmol） morphine in rats with neuropathic *** together,our results suggested that GluA2.trafficking in the PAG plays a critical role in pain modulation,and inhibiting GluA2.endocytosis with GluA_（2.3y） has potent analgesic effects in rats with neuropathic *** findings strongly support the recent hypothesis that targeting receptor trafficking could be a new strategy for the treatment of neuropathic pain.

关键词： periaqueductal grey AMPA receptor GluA2.3y internalization morphine hindpaw withdrawal latency

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不同覆盖物对芦笋品质和春季产量的影响

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湖南农业科学 2024年第8期 10-14页

作者：刘奇颀郑永昕文文祝腾辉杨帆李虎余格辉岳阳市农业科学研究院湖南岳阳414000

为促进设施栽培芦笋春季早发,提升芦笋春季产量,以“CD-12.为供试材料,设置稻壳、芦笋秸秆、拱棚、拱棚+稻壳、拱棚+芦笋秸秆5种覆盖方式,比较不同覆盖物对芦笋品质和春季产量的影响。结果表明:5种覆盖方式均能提高地温,促进芦笋早发,... 详细信息

为促进设施栽培芦笋春季早发,提升芦笋春季产量,以“CD-12.为供试材料,设置稻壳、芦笋秸秆、拱棚、拱棚+稻壳、拱棚+芦笋秸秆5种覆盖方式,比较不同覆盖物对芦笋品质和春季产量的影响。结果表明:5种覆盖方式均能提高地温,促进芦笋早发,但2.复合覆盖处理方式升温效果较为显著,其中,拱棚+芦笋秸秆的效果最佳,可提高15 cm地温2.5~7.5℃,比对照提前12.d进行采收,整个采收期产量较对照增产36.39%,净收入效益增幅可达47.46%;拱棚+稻壳产量较对照增产2..01%,但成本较拱棚+芦笋秸秆处理高。单一覆盖处理中,拱棚的升温效果略好,产值较对照提高11.80%,但因覆盖成本较高,净收入相较对照并无优势;而稻壳、芦笋秸秆覆盖处理对芦笋产量和经济效益并无明显提升。

关键词：芦笋早春覆盖拱棚芦笋秸秆产量经济效益

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Greatly enhanced mechanical properties of thermoelectric SnSe through microstructure engineering

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Journal of Advanced Ceramics 2023年第5期12卷 1081-1089页

作者： Chen Chen Bin-Hao Wang Chen Chen Hai-Dong Zhao Bin Zhang Dan Wang Tao Shen Peng-Hui Li Song Zhao Dong-Li yu yong-Jun Tian Bo Xu Center for High Pressure Science(CHiPS) State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China School of Physical Sciences Great Bay UniversityDongguan 523000China

The outstanding thermoelectric material, SnSe, is also known for its inferior mechanical properties, which bring great inconvenience for its application in thermoelectric devices. In this work, SnSe bulks were prepared via a sequential procedure of high-pressure synthesis (HPS), ball milling, and spark plasma sintering (SPS). The produced polycrystalline samples with a unique microstructure of tightly-bound quasi-equiaxed grains exhibited excellent mechanical properties. The Vickers hardness (HV), compressive strength (σ_(c)), and bending strength (σ_(b)) reached 1.1 GPa, 300 MPa, and 90 MPa, respectively, all of which are far superior to those of ordinary polycrystalline SnSe. Furthermore, the microstructures did not deteriorate thermoelectric performance. This work demonstrated an effective procedure to prepare polycrystalline microstructure-engineered SnSe materials, which not only show advantages in device applications but also shed light on property enhancement for other layer-structured thermoelectric materials.

关键词： thermoelectric materials SnSe mechanical properties hardness

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I_(2.-Mediated[3+2.annulation of methyl-azaarenes with alkyl_(2.-isocyanoacetates or amino acid ester hydrochlorides:selective synthesis of iodine-func-tionalized and non-iodine-functionalized fused imidazoles

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Organic Chemistry Frontiers 2022年第5期9卷 1403-1409页

作者： yong-Ji Hu yu Zhou Jing-Jing Gao Han Zhang Kai-Rui Yang Jia-Jun Li Xiao-Xin Yan yuan-Lin Li Yan-Ping Zhu School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug EvaluationMinistry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityShandongYantai264005P.R.China

An I_(2.-mediated[3+2.annulation of methyl-azaarenes with alkyl_(2.-isocyanoacetates or amino acid ester hydrochlorides has been *** strategy involves CuN bond cleavage of isocyanides and can selectively synthesize iodine-functionalized and non-iodine-functionalized fused ***-up experiments and arylation,alkynylation,alkenylation and selenization of iodine-functionalized products demonstrated the potential applications of this reaction.

关键词： reaction iodine fused

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雷视在线流量监测系统在邹圩水文站的应用

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广西水利水电 2024年第5期 107-110,114页

作者：杨彩萍黄祖森刘详勇于松松何术利南宁水文中心宾阳水文中心站广西宾阳530000 华为技术有限公司广东深圳

综合考虑雷达法和视频法的技术优势和不足,通过二者在表面流速及断面流量测量方面的融合实现互补,达到全场景、全量程、高精度、易标定的系统设计目标,提升流量全过程在线监测精度,实现水文高质量发展。

关键词：华为雷达视频融合技术非接触式测流自动化监测

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The Subtelomere of Oryza sativa Chromosome 3 Short Arm as a Hot Bed of New Gene Origination in Rice

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Molecular Plant 2008年第5期1卷 839-850页

作者： Chuanzhu Fana yong Zhang Yeisoo yu Steve Rounsley Manyuan Long Rod A. Wing Arizona Genomics Institute Department of Plant Sciences University of Arizona Tucson AZ 85721 USA Department of Ecology and Evolution University of Chicago Chicago IL 60637 USA BIO5 Institute for Collaborative Research University of Arizona Tucson AZ 85721 USA

Despite general observations of non-random genomic distribution of new genes, it is unclear whether or not new genes preferentially occur in certain genomic regions driven by related molecular mechanisms. Using 1.5 Mb of genomic sequences from short arms of chromosome 3 of Oryza glaberrima and O. punctata, we conducted a comparative genomic analysis with the reference O. sativa ssp. japonica genome. We identified a 60-kb segment located in the middle of the subtelomeric region of chromosome 3, which is unique to the species O. sativa. The region contained gene duplicates that occurred in Asian cultivated rice species that diverged from the ancestor of Asian and African cultivated rice one million years ago （MYA）. For the 12.genes and one complete retrotransposon identified in this segment in O. sativa ssp. japonica, we searched for their parental genes. The high similarity between duplicated paralogs further supports the recent origination of these genes. We found that this segment was recently generated through multiple independent gene recombination and transposon insertion events. Among the 12.genes, we found that five had chimeric gene structures derived from multiple parental genes. Nine out of the 12.new genes seem to be functional, as suggested by Ka/Ks analysis and the presence of cDNA and/or MPSS data. Furthermore, for the eight transcribed genes, at least two genes could be classified as defense or stress response-related genes. Given these findings, and the fact that subtelomeres are associated with high rates of recombination and transcription, it is likely that subtelomeres may facilitate gene recombination and transposon insertions and serve as hot spots for new gene origination in rice genomes.

关键词： comparative genomics gene duplication Oryza sativa subtelomere new genes.

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不同剂量甲苯磺酸瑞马唑仑在老年全身麻醉手术患者麻醉诱导中的应用效果

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中国药物经济学 2024年第1期19卷 55-58页

作者：管全胜刘志军谭东霞李永星蒋松余良胜湖北理工学院附属黄石爱康医院麻醉科湖北黄石435000 武汉市汉口医院麻醉科武汉430000 黄石市第五医院麻醉科湖北黄石435005

目的探讨不同剂量甲苯磺酸瑞马唑仑在老年全身麻醉手术患者麻醉诱导中的应用效果。方法选取于湖北理工学院附属黄石爱康医院接受全身麻醉手术的12.例老年患者作为研究对象,均采用甲苯磺酸瑞马唑仑进行麻醉诱导,采用随机数字表法分为低... 详细信息

目的探讨不同剂量甲苯磺酸瑞马唑仑在老年全身麻醉手术患者麻醉诱导中的应用效果。方法选取于湖北理工学院附属黄石爱康医院接受全身麻醉手术的12.例老年患者作为研究对象,均采用甲苯磺酸瑞马唑仑进行麻醉诱导,采用随机数字表法分为低剂量组(0.2.mg/kg)、中剂量组(0.3 mg/kg)、高剂量组(0.4 mg/kg),各40例。比较3组患者血流动力学指标[心率(HR)、平均动脉压(MAP)、动脉血氧饱和度(SaO_(2.)]、麻醉诱导及苏醒质量、镇静深度[脑电双频指数(BIS)值、改良警觉/镇静评分量表(MOAA/S)评分]及不良反应。结果3组患者麻醉诱导前及气管插管后MAP、SaO_(2.比较,差异无统计学意义(P>0.05);气管插管后,中、高剂量组HR显著低于低剂量组(P0.05)。中、高剂量组麻醉起效时间显著短于低剂量组(P0.05)。3组麻醉诱导前BIS值、MOAA/S评分差异均无统计学意义(P>0.05);气管插管后,中剂量组、高剂量组BIS值均显著低于低剂量组(P0.05)。3组不良反应发生率比较,差异无统计学意义(P>0.05)。结论老年全身麻醉手术患者采用0.3 mg/kg甲苯磺酸瑞马唑仑麻醉诱导,血流动力学指标稳定,麻醉、苏醒质量高,且镇静深度理想。

关键词：甲苯磺酸瑞马唑仑全身麻醉麻醉诱导血流动力学镇静深度

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自行走高空车平台调平技术研究

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液压气动与密封 2024年第8期44卷 91-94页

作者：程旭华古彬宏姜玉勇方百富张晓康太重集团(西安)装备技术有限公司陕西西安712000

随着现代建筑行业的快速发展,自行走高空车的需求日益增长。其中,调平技术作为车辆稳定运行和操作人员安全性的关键因素,受到了广泛关注。通过对高空车平台运用的三种主流调平技术进行研究,探讨了其工作原理、实际应用效果及自行走高空... 详细信息

随着现代建筑行业的快速发展,自行走高空车的需求日益增长。其中,调平技术作为车辆稳定运行和操作人员安全性的关键因素,受到了广泛关注。通过对高空车平台运用的三种主流调平技术进行研究,探讨了其工作原理、实际应用效果及自行走高空车未来发展方向。

关键词：自行走高空车机械调平静液压调平电液调平

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Transition from the Southern Mode of the Mei-yu Front Cloud System to Other Leading Modes

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Advances in Atmospheric Sciences 2014年第4期31卷 948-961页

作者： QIN Danyu LI Bo HUANG yong Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites China Meteorological Administration Institute of Satellite Meteorology National Satellite Meteorological CenterChina Meteorological Administration School of Atmospheric Physics Nanjing University of Information Science and Technology Anhui Institute of Meteorology Science

Based on normalized six-hourly black body temperature （TBB） data of three geostationary meteorological satellites,the leading modes of the mei-yu cloud system between 1998 and 2.08 were extracted by the Empirical Orthogonal Function （EOF） method,and the transition processes from the first typical leading mode to other leading modes were discussed and *** analysis shows that,when the southern mode （EOF1） transforms to the northeastern mode （EOF3）,in the mid-troposphere,a low trough develops and moves southeastward over central and eastern *** circulation pattern is characterized by two highs and one low in the lower troposphere.A belt of low pressure is sandwiched between the weak high over central and western China and the strong western North Pacific subtropical high （WNPSH）.Cold air moves southward along the northerly flow behind the low,and meets the warm and moist air between the WNPSH and the forepart of the low trough,which leads to continuous *** the same time,the central extent of the WNPSH increases while its ridge extends *** addition,transitions from the southern mode to the dual centers mode and the tropical-low-influenced mode were found to be atypical,and so no common points could be ***,the choice of threshold value can affect the number of samples discussed.

关键词： black body temperature mei-yu front cloud system leading modes mode transition

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犬和猫皮肤癣菌三重荧光定量PCR检测方法的建立及应用

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动物医学进展 2024年第9期45卷 56-60页

作者：徐博郭思宇纪佳豪李梓豪刘文扬勾永志白二钢李睿文河北农业大学动物医学院河北保定071000 保定市动物疾病预防控制中心河北保定071000 河北创安生物科技有限公司河北保定071000

建立鉴别犬小孢子菌(Microsporum canis,MC)、须癣毛癣菌(Trichophyton mentagrophytes,TM)和秕糠马拉色菌(Malassezia furfur,MF)的三重荧光PCR检测方法,根据MC、TM和MF 3种真菌的ITS基因保守序列设计引物和探针,建立三重荧光PCR检测方法。所建立的三重荧光PCR方法仅对MC、TM和MF出现阳性扩增,与大肠埃希氏菌、产色葡萄球菌和铜绿假单胞菌等犬、猫皮肤病常见病原无交叉反应,对MC、TM和MF的最低检出限分别为1.36×10^(1)、1.35×10^(1)、1.33×10^(1)拷贝;组内和组间变异系数均小于2.,重复性好。应用建立三重荧光PCR方法对88份犬、猫临床样品进行检测,结果检出1份MC阳性、2.份TM阳性、2.份MF阳性,检测结果与单一荧光PCR方法一致。该方法可对MC、TM和MF同时快速检测,可用于犬、猫真菌性皮肤病的快速诊断。

关键词：犬和猫皮肤病犬小孢子菌须癣毛癣菌秕糠马拉色菌三重荧光PCR

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