I_(2)-Mediated[3+2]annulation of methyl-azaarenes with alkyl_(2)-isocyanoacetates or amino acid ester hydrochlorides:selective synthesis of iodine-func-tionalized and non-iodine-functionalized fused imidazoles

作     者：Yong-Ji Hu Yu Zhou Jing-Jing Gao Han Zhang Kai-Rui Yang Jia-Jun Li Xiao-Xin Yan Yuan-Lin Li Yan-Ping Zhu 

作者机构：School of PharmacyKey Laboratory of Molecular Pharmacology and Drug EvaluationMinistry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityShandongYantai264005P.R.China 

出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)

年 卷 期：2022年第9卷第5期

页      面：1403-1409页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by the National Natural Science Foundation of China(21702091) Science and Technology Innovation Development Plan of Yantai(2020MSGY114) Yantai“Double Hundred Plan” The authors also thank the Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shandong Province The Graduate Innovation Foundation of Yantai University(YDYB2128)is gratefully acknowledged(for Y.-J.Hu) 

主　　题：reaction iodine fused 

摘      要：An I_(2)-mediated[3+2]annulation of methyl-azaarenes with alkyl_(2)-isocyanoacetates or amino acid ester hydrochlorides has been *** strategy involves CuN bond cleavage of isocyanides and can selectively synthesize iodine-functionalized and non-iodine-functionalized fused ***-up experiments and arylation,alkynylation,alkenylation and selenization of iodine-functionalized products demonstrated the potential applications of this reaction.