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检索条件"任意字段=2012长三角药物化学研讨会"
共 118 条 记 录，以下是91-100 订阅
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Direct C3-alkenylation of pyridin-4(1H)-one via oxidative Heck coupling
Direct C3-alkenylation of pyridin-4(1H)-one via oxidative He...
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2012长三角药物化学研讨会
作者： Guangling Zhang Ziyuan Li Yue Huang Jinyi Xu Xiaoming Wu Hequan Yao State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry China Pharmaceutical University
During the last few decades,major progress has been achieved in transition metal catalyzed carbon(sp2)-carbon(sp2) *** them,Heck reaction between halogenated arenes with alkenes is recognized as one of the most powerf...
来源： cnki会议 评论
A Five Featured Pharmacophore Model for the Sodium-Dependent Glucose Co-Transporter 2(SGLT2)Inhibitors
A Five Featured Pharmacophore Model for the Sodium-Dependent...
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2012长三角药物化学研讨会
作者： 徐聪颖 李卫华 刘桂霞 唐赟 上海市新药设计重点实验室 华东理工大学药学院
As we all know,type 2 diabetes is dangerous to our *** year 2010,there are about 92 million diabetic patients in *** sodium-dependent glucose co-transporter 2 is currently one of the most widely studied targets of typ...
来源： cnki会议 评论
Insights into the agonist binding mechanism of human CB2 receptor by molecular dynamics simulation,free energy calculation and 3D-QSAR studies
Insights into the agonist binding mechanism of human CB2 rec...
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2012长三角药物化学研讨会
作者： Jiong-Jiong Chen Jian-Zhong Chen ZJU-ENS joint laboratory of medicinal chemistry College of Pharmaceutical ScienceZhejiang University
CB2 selective agonists have drawn attention in drug discovery,since CB2 becomes a promising target for the treatment of neuropathic pain without psychoactive or other CNS-related side ***, due to the lack of experimen...
来源： cnki会议 评论
Discovery of novel arylsulfonyl quinoxalines as PI3Kαinhibitors for the treatment of cancer
Discovery of novel arylsulfonyl quinoxalines as PI3Kαinhibi...
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2012长三角药物化学研讨会
作者： Xiaoqing Lv Peng Wu Bo Yang Qiaojun He Yongzhou Hu ZJU-ENS Joint laboratory of Medicinal Chemistry College of Pharmaceutical SciencesZhejiang University Institute of Pharmacology and Toxicology College of Pharmaceutical SciencesZhejiang University
Phosphoinositide 3-kinases(PI3Ks) are lipid kinases which have been found in many cellular processes,including glucose homeostasis,metabolism,survival,proliferation and *** amplification or over-expression of PI3Ks co... 详细信息
来源： cnki会议 评论
Design,Synthesis and Biological Evaluation of Benzothiazepinones(BTZs)as Non-ATP Competitive Inhibitors of Glycogen Synthase Kinase-3β(GSK-3β)
Design,Synthesis and Biological Evaluation of Benzothiazepin...
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2012长三角药物化学研讨会
作者： Peng Zhang Yong Chu De-Yong Ye Department of Medicinal Chemistry School of PharmacyFudan University
Glycogen synthase kinase-3β(GSK-3β) plays a key role in the regulation of many physiological responses in mammalian cells as a multifunctional serine/threonine protein kinase [1].Its phosphorylation process controls...
来源： cnki会议 评论
Novel Dual-Site-Binding Neuraminidase Inhibitor from Virtual Screening by Pharmacophore and Molecular Dynamics Methods
Novel Dual-Site-Binding Neuraminidase Inhibitor from Virtual...
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2012长三角药物化学研讨会
作者： Jiang Zhengyu Huang Kun Wu Xiaowen Sun Haopeng You Qidong Department of Medicinal Chemistry China Pharmaceutical University State Key Laboratory of Natural Medicines Department of Medicinal ChemistryChina Pharmaceutical University Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University
Neuraminidase is a significant anti-influenza target that plays crucial role in virus replication cycle. The discovery of 150-cavity in Group-1 neuraminidase provides us a novel mentality of designing inhibitor which ...
来源： cnki会议 评论
Pharmacophore-Based Drug Design and Biological Evaluation of Novel ABCB1 Inhibitors
Pharmacophore-Based Drug Design and Biological Evaluation of...
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2012长三角药物化学研讨会
作者： Sheng-lie Zhang Yin-xiang Wei Qian Li Hao-peng Sun Hui Peng Qi-dong You
Overexpression of ABCB1 is one of major barriers for multidrug resistance in chemotherapy and limits drug oral *** of ABCBl would sensitize MDR in clinical cancer *** this aim,a 3D pharmacophore model was created base... 详细信息
来源： cnki会议 评论
Discovery of novel inhibitor of signal transducer and activator of transcription 3(STAT3)signaling pathway by virtual screening
Discovery of novel inhibitor of signal transducer and activa...
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2012长三角药物化学研讨会
作者： 张鸣鸣 朱雪莲 朱维良 李英霞 School of pharmacy Fudan University Shanghai Institute of material medica Chinese Academy of Science
Inhibition of the signal transducer and activator of transcription 3(STAT3) signaling pathway has been considered a novel therapeutic strategy to treat human cancers that harbor aberrantly-active *** this study,nearly...
来源： cnki会议 评论
Design,Synthesis and Evaluation of Indolebutylamines as a Novel Class of Selective Dopamine D3 Receptor Ligands
Design,Synthesis and Evaluation of Indolebutylamines as a No...
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2012长三角药物化学研讨会
作者： 徐丽丽 杜鹏 于坤千 赵伟利 镇学初 付伟 复旦大学药学院药物化学教研室 上海药物研究所 苏州大学药学院药理教研室
D3R has been proved to be a promising therapeutic target for the treatment of schizophrenia, Parkinson’s disease,drug-induced dyskinesia,drug addiction/and drug ***, function study of D3R in vivo is limited due to th...
来源： cnki会议 评论
Discovery,Synthesis and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53-MDM2 Protein-Protein Interaction
Discovery,Synthesis and Biological Evaluation of Orally Acti...
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2012长三角药物化学研讨会
作者： 庄春林 繆震元 盛春泉 张万年 School of Pharmacy Second Military Medical University
The p53-MDM2 interaction has been approved to be a valuable target to develop effective antitumor *** p53-MDM2 inhibitors bearing pyrrolidone scaffolds were successfully identified by structure-based *** nanomolar inh...
来源： cnki会议 评论
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