Design,Synthesis and Biological Evaluation of Benzothiazepinones(BTZs)as Non-ATP Competitive Inhibitors of Glycogen Synthase Kinase-3β(GSK-3β)
作者单位：Department of Medicinal ChemistrySchool of PharmacyFudan University
会议名称：《2012长三角药物化学研讨会》
会议日期：2012年
学科分类：1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学]
摘 要：Glycogen synthase kinase-3β(GSK-3β) plays a key role in the regulation of many physiological responses in mammalian cells as a multifunctional serine/threonine protein kinase [1].Its phosphorylation process controls a multitude of cellular processes,including gene transcription,metabolic pathways,cell growth and differentiation,as well as apoptosis[2].Thus, inhibition of GSK-3P may represent a novel approach for the therapy of several human diseases, such as typeⅡdiabetes,Alzheimer’s diseases(AD),chronic inflammatory diseases,bipolar disorders and cancer[3].