Bioactivity and antibacterial effect of nitrogen plasma immersion ion implantation on PEEK of dental implant materials
作者单位：郑州大学第一附属医院
会议名称：《中华口腔医学会全科口腔医学专业委员会第八次学术会议》
会议日期：2017年
学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
关 键 词：plasma immersion ion implantation bioactivity antibacterial
摘 要：Objective:The aim of this present study was to investigate the bioactivity and antibacterial effect of nitrogen Pill modification on PEEK.Finally,we lay a foundation for their widespread clinical application of PEEK and its composites in the field of dental implant,bone defect repair and joint replacement.Methods:According to the different modified parameters,the PEEK specimens were randomly divided into four main groups(n=49/group):PEEK-C,PEEK-1,PEEK-L,and PEEK-H.Then,N2-PIII surface modification was conducted using the corresponding parameters.The microstructure and composition of the modified PEEK surface was observed by scanning electron microscope(SEM),atomic force microscopy(AFM) and X-ray photoelectron spectroscopy(XPS).The water contact angle of the PEEK surface was also studied by contact angle meters.The bioactive ability of PEEK samples was evaluated by observing the attachment,proliferation,and differentiation of MG63 cells cultured on the PEEK samples.Antibacterial property of the samples against Staphylococcus aureus was detected with the plate colony-counting methods.Results:SEM and AFM analysis shows that PEEK-C surface is relatively smooth with the Ra value of 50.6±2.52 nm.PEEK-1 and PEEK-L surface is rough with the Ra value of 435.916.47 nm and443.2315.49 nm,respectively,and the PEEK-H surface is the most rough with the Ra value of 608.4±3.14 nm.XPS element analysis demonstrated that nitrogen functional groups were successfully introduced into the surface of PIII-modified PEEK.Biological evaluation and the antibacterial results showed that nitrogen Pill treatment can significantly improve the biological activity of PEEK,and samples showed antibacterial properties against Staphylococcus aureus.Conclusions:PEEK surface subjected to the N2-PIII treatment showed better biological activity and antibacterial effect.Therefore,N2-PIII-treated PEEK surface is promising in bone tissue engineering and dental applications.