A STUDY ON ALKALINE PHOSPHATASE ISOENZYMES ASSOCIATED WITH GLUCOCORTICOID HEPATOPATHY IN THE DOG
作者单位：Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine Veterinary Teaching Hospital Faculty of Agriculture Iwate University
会议名称：《面向21世纪的动物科学与动物医学国际研讨会》
会议日期：2000年
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
关 键 词：Dog Alkaline phosphatase Isoenzyme Glucocorticoid hepatopathy Ultrasonography
摘 要：正Glucocortlcold hepatopathy（GH） is known in dogs with endogenous hypercortisollsm and in dogs receiving exogenous glucocorticoids. The hepatopathy is characterized histologically by a pattern of cytoplasmic vacuolization and biochemically by induction of liver enzymes, especially the corticosteroid-induced alkaline phosphates（CALP） that is unique to dogs. We investigated the relationship between serum ALP isoenzymes and the degree of GH. The degree of hepatopathy was quantified using vacuolization scores under light microscopy and degree of hepatopathy was quantified using vacuolization scores under light microscopy and digital analysis of hepatic parenchymal histograms using a ultrasonographic electronic scanner