A Unique C-N Breakage of Sulfonylated Cyclic Amines by Azole Ring to Access Novel Antimicrobial Sulfonamide Azoles
作者单位：Shandong Provincial Engineering Technology Research Center for Lunan Chinese Herbal MedicineLinyi University School of Chemistry and Chemical EngineeringSouthwest University
会议名称：《中国化学会全国第十二届有机合成化学学术研讨会》
会议日期：2015年
学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学]
基 金：国家自然科学基金(No.21172181 21372186 81450110094)资助项目
关 键 词：sulfonamide C-N breaking imidazole triazole
摘 要：Sulfonamides are extensively employed as artificial antifolic agents for the prevention and cure of bacterial infections in human biological systems and a large amount of their heterocyclic derivatives such as pyrimidines has been developed and *** has been continuously attracting an increasing interest towards heterocyclic azole derivatives of sulfonamides,especially their highly efficient synthesis towards bioactive sulfonamide derivatives with heterocyclic *** a unique ring-opening reaction of C-N breakage of sulfonylated cyclic amine by azole ring to access novel antimicrobial sulfonamide azoles was *** single-crystals of the prepared compounds were cultured and determined by X-ray analysis in order to confirm this *** important influential factors including temperature,solvent and reaction time for this unique reaction were also *** the newly prepared compounds were screened for their antimicrobial activities.