检索结果-南通市图书馆

Influence of reclaimed water discharge on the dissemination and relationships of sulfonamide, sulfonamide resistance genes along the Chaobai River, Beijing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2019年第1期13卷 87-98页

作者： Ning Zhang Xiang Liu Rui Liu Tao Zhang Miao Li Zhuoran Zhang Zitao Qu Ziting Yuan Hechun Yu School of Environment Tsinghua University Beijing 100084 China Division of Environment and Resources Research Transport Planning and Research Institute Ministry of Transport Beijing 100028 China Chinese Academy for Environmental Planning Beijing 100012 China Institute of Chemistry Industrial Chemistry Technical University of Munich (Asian Campus) Singapore 139660 Singapore School of Water Resources and Environment China University of Geosciences (Beijing) Beijing 100083 China

Reclaimed water represents an important source of antibiotics and antibiotic resistance genes, threatening the ecological safety of receiving environments, while alleviating water resource shortages. This study investigated the dissemination of sulfonamide (SAs), sulfonamide resistance genes (SRGs), and class one integrons (intl1) in the surface water of the recharging area of the Chaobai River. The three antibiotics sulfamethoxazole, trimethoprim, and sulfadiazine had the highest abundance. The highest absolute abundances were 2.91×10^6, 6.94×10^6, and 2.18×10^4 copies/mL for sul1, sul2, and intl 1 at the recharge point, respectively. SRGs and intl1 were widespread and had high abundance not only at the recharging point, but also in remote areas up to 8 km away. Seasonal variations of SRGs abundance followed the order of summer>autumn>spring>winter. Significant correlations were found between SRGs and intl1 (a = 0.887 and 0.786, p<0.01), indicating the potential risk of SRGs dissemination. Strong correlations between the abundance of SRGs and environmental factors were also found, suggesting that appropriate environmental conditions favor the spread of SRGs. The obtained results indicate that recharging with reclaimed water causes dissemination and enrichment of SAs and SRGs in the receiving river. Further research is required for the risk assessment and scientific management of reclaimed water.

关键词： sulfonamide residues sulfonamide resistance genes Reclaimed water recharge Surface water Class one integrons

Crystal and Molecular Structure of N-(Pyridin-2-yl-carbonyl)-2-ethoxycarbonyl-benzene sulfonamide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2002年第3期21卷 284-287页

作者：姜林李正名翁林红冷雪冰 College of Science Shandong Agricultural University Taian 271018 ChinaNational Key Laboratory of Elemento-organic Chemistry Elemento-organic Chemistry Institute Nankai University Tianjin 300071 China National Key Laboratory of Elemento-organic Chemistry Elemento-organic Chemistry Institute Nankai University Tianjin 300071 China

The crystal and molecular structures of the title compound (C15H14N2O5S, Mr = 334.34) were determined by X-ray diffraction. The crystal structure is of triclinic, space group P with a = 7.306(1), b = 7.933(1), c =14.146(2) ?, a = 81.95, b = 80.28, g = 72.92? V = 768.9(2) 3, Z = 2, Dc = 1.444 g/cm3 , = 0.238mm-1, F(000) = 348, S = 1.033, the final R = 0.0453 and wR = 0.1181 for 2704 observed reflections with I >2s(I). In the molecule there are three different planes. In each of them a conjugated system is formed. The intra-molecular hydrogen bond between N and H atoms was ascertained and a five-membered ring including hydrogen bond is formed.

关键词： sulfonamide synthesis crystal structure

Lithium(fluorosulfonyl)(n-nonafluorobutanesulfonyl)imide for stabilizing cathode-electrolyte interface in sulfonamide electrolytes

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第7期16卷 9507-9518页

作者： Hao Wu Ziyu Song Wenfang Feng Zhibin Zhou Heng Zhang Key Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education) School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Rechargeable lithium metal batteries(RLMBs)have been regarded as promising successors for contemporary lithium-ion batteries,in view of their high gravimetric and volumetric energy *** non-aqueous liquid electrolytes containing organic carbonate solvents possess high chemical reactivities with metallic lithium anode and high flammability,which induces considerable safety threats under extreme conditions(e.g.,overcharging and thermal runaway).Herein,we propose the utilization of fluorinated sulfonamide(i.e.,N,N-dimethyl fluorosulfonamide(DMFSA))as solvent,together with lithium(fluorosulfonyl)(n-nonafluorobutanesulfonyl)imide(LiFNFSI)as co-salt and/or electrolyte additive for accessing safer and highperforming *** physical(e.g.,thermal transition,viscosity,and ionic conductivity)and electrochemical(e.g.,anodic stability on different electrodes)characterizations have been performed,aiming to reveal the inherent characteristics of the sulfonamide-based electrolytes and the particular role of LiFNFSI on the stabilization of LiCoO_(2) *** has been demonstrated that the sulfonamide-based electrolytes exhibit superior flame-retardant abilities and decent ionic conductivities(>1 mS·cm^(-1)at room temperature).The incorporation of LiFNFSI as co-salt and/or electrolyte additive could significantly suppress the side reactions occurring at the cathode compartment,through the preferential decompositions of the *** work is anticipated to give an in-depth understanding on the working mechanism of LiFNFSI in the sulfonamide-based electrolytes,and also spurs the development of high-energy and safer RLMBs.

关键词： lithium metal batteries lithium(fluorosulfonyl)(n-nonafluorobutanesulfonyl)imide sulfonamide non-flammable electrolyte cathode stabilization

Design, synthesis and in vitro antitumor evaluation of novel diaryl urea derivatives bearing sulfonamide moiety

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2013年第11期56卷 1564-1572页

作者： LUO Can TANG Ke LI Yan YIN DaLi CHEN XiaoGuang HUANG HaiHong Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation Institute of Materia Medica Peking Union Medical College & Chinese Academy of Medical Sciences

A novel series of diaryl urea derivatives bearing sulfonamide moiety have been designed and synthesized. Their in vitro antitumor effect against human cancer cell lines MX-1, A375, HepG2, Ketr3 and HT-29 was screened and evaluated by the standard MTT assay with sorafenib as the positive control. Some of the compounds showed significant inhibitory activity against multiple cell lines compared to sorafenib. In particular, 2,6-dimethyl-4-{6-[3-（4-chloro-3-（trifluoromethyl）phenyl）urealnaphthalen- 2-yllsulfonyl morpholine （10d） was found to be the most potent against A375, HepG2 and Ketr3 with ICs0 values of 0.65-0.97 μmol/L, which were 5-20-fold more potent than sorafenib. Compound 10d emerged as a valuable lead for further optimization.

关键词： diaryl urea derivatives sulfonamide sorafenib antitumor activity

In Situ Generation of Oxazole Ylide and Interception with sulfonamide： Construction of Amidines Using Two Diazo Molecules

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2018年第9期36卷 857-865页

作者： Jijun Chen Wenhao Long Yanwei Zhao Haiyan Li Yonggao Zheng Pengcheng Lian Xiaobing Wan Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China

A novel generation of oxazole vlide and interception with sulfonamide have been well developed to construct fully substituted amidines. This copper-catalyzed four-component reaction incorporates two diazo molecules to target amidines and shows broad substrate scope, excellent functional groups tolerance and good to excellent yields.

关键词： oxazole ylide sulfonamide diazo compounds amidines

Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第6期13卷 2747-2764页

作者： Shenghua Gao Letian Song Yusen Cheng Fabao Zhao Dongwei Kang Shu Song Mianling Yang Bing Ye Wei Zhao Yajie Tang Erik De Clercq Christophe Pannecouque Peng Zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical BiologyMinistry of EducationSchool of Pharmaceutical SciencesShandong UniversityJi'nan 250012China China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Ji'nan 250012China Rega Institute for Medical Research K.U.LeuvenMinderbroedersstraat 10Leuven B-3000Belgium Shenzhen Research Institute of Shandong University A301 Virtual University Park in South District of ShenzhenShenzhen 518057China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

Indolylarylsulfones(IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors(NNRTIs) with a unique scaffold and possess potent antiviral *** address the high cytotoxicity and improve safety profiles of IASs,we introduced various sulfonamide groups linked by alkyl diamine chain to explore the entrance channel of non-nucleoside inhibitors binding pocket.48 compounds were designed and synthesized to evaluate their anti-HIV-1 activities and reverse transcriptase inhibition ***,compound R_(10)L_(4) was endowed with significant inhibitory activity towards wild-type HIV-1(EC_(50(WT))=0.007μmol/L,SI=30,930) as well as a panel of single-mutant strains exemplified by L100I(EC_(50)=0.017μmol/L,SI=13,055),E138K(EC_(50)=0.017μmol/L,SI=13,123) and Y181C(EC_(50)=0.045μmol/L,SI=4753) which were superior to Nevirapine and ***,R_(10)L_(4) was characterized with significantly reduced cytotoxicity(CC_(50)=216.51μmol/L) and showed no remarkable in vivo toxic effects(acute and subacute toxicity).Moreover,the computer-based docking study was also employed to characterize the binding mode between R_(10)L_(4) and HIV-1 ***,R_(10)L_(4) presented an acceptable pharmacokinetic ***,these results deliver precious insights for next optimization and indicate that the sulfonamide IAS derivatives are promising NNRTIs for further development.

关键词： HIV-1 NNRTIs Indolylarylsulfone sulfonamide Cytotoxicity

Asymmetric Transfer Hydrogenation of Ketone Catalyzed by Novel Ru(Ⅱ)-Chiral sulfonamide Complex

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2000年第5期11卷 383-384页

作者： Chun E DONG Jun Long ZHANG Wei Zhong ZHENG Zuo Long YU Liang Fu ZHANG (Chengdu Institute of organic Chemistry Academ Sinica. Chengdu 610041) Chengdu Inst. Organ. Chem. Academ S. Chengdu 610041 China

Two new chiral Ru(Ⅱ)-sulfonamide complex have been used to catalyze the enantioselective transfer hydrogenation of prochiral ketones and the secondary alcohols are obtained with good to excellent optical yields.

关键词： sulfonamide transfer hydrogenation.

Investigation of Breaking Efficiency of N-Glycosidic Bond Between sulfonamide and Honey

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2012年第2期28卷 195-199页

作者： WANG Yan-hua LI Li CHEN Chia-hung CHENG Shuenn-ren LEE Mu-sheng YU Pu-ping CHANG-CHIEN Guo-ping College of Biology and Enviornmental Engineering Zhejiang Shuren University Hangzhou 310015 P. R. China Super Micro Mass Research ＆ Technology Center Department of Business Administration Department of Mechanical Engineering Cheng Shiu University Kaohsiung 833 Taiwan P. R. China Environmental Protection Bureau Kaohsiung City Government Keelung 20143 Taiwan P. R. China

sulfonamide residue in honey existed in a form bonded to sugar via the N-glycosidic *** would result in the possible underestimation of concentration of sulfonamide if it is not decomposed by chemical ***,in China's Mainland and Taiwan（***）,the regulation for sulfonamide residue analysis does not include hydrolysis and has been applied to a very broad range of samples,for example,egg,milk,meat,seafood as well as *** paper demonstrates the necessity of hydrolysis of it prior to extracting *** breaking efficiencies of N-glycosidic bond were investigated by 2 mol/L hydrochloric acid,pure methanol and 0.5 mol/L hydrochloric acid in methanol,*** was found that acid plays the key role in breaking the N-glycosidic bond,and it was also noticed that the dissolution of liberated sulfonamide in methanol could carry the reaction forward in favor of breaking the N-glycosidic bond.

关键词： sulfonamide Honey Liquid chromatography-electrospray ionization tandem mass spectrometry(LC-ESIMS/MS) N-Glycosidic bond

Design, synthesis and bioactivity of novel ALS enzyme inhibitors (II)——Molecular mechanics, quantum chemistry and structure-activity relationship studies on the herbicidal heterocyclic sulfonamide

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 1996年第1期39卷 78-85页

作者：陆荣健杨华铮尚贞锋汪惟为潘荫明赵学庄 Institute of Elemento-Organic Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Department of Chemistry Nankai University Tianjin 300071 China

In view of quantum pharmacology, the structure-activity relationships of different kinds of fused heterocydic sulfonamides with the same mode of action were first investigated using molecular mechanics, quantum chemistry and discriminatory analysis. It has been found that the process of the interaction of the fused heterocydic sulfonamide with ALS enzyme involves the electropositive region of the sulfonyl bridge chain and the electronegative region of the heterocydic moiety. The herbicidal activity is related to the potency of electric charge translocation of the related regions.

关键词： fused heterocyclic sulfonamide ALS enzyme inhibitor structure-activity relationship quantum pharmacology sulfonylurea.