Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii
作者单位：Center for Parasitic OrganismsState Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-Sen University Ecosystems and Environment and Biomedical Research CentresSchool of Environment and Life SciencesUniversity of Salford The Key Laboratories of Pathogen Biology and ZoonosesAnhui Province and Department of ParasitologyAnhui Medical University Department of Ecology and Evolutionary BiologyUniversity of California
会议名称：《中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会》
会议日期：2015年
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
基 金：supported by grants from National Base Research program(973 project)(NO.2010CB530000) National Natural Science Foundation of China(#31272305,#31472058,#31301876 and#31402029) Academic Degrees Committee of Guangdong Province(SYBZZXM201011)
关 键 词：Malignancy single cell organisms mammals evolution transmissible
摘 要：Cancer is a general name for more than 100 malignant *** is postulated that all cancers start from a single abnormal cell that grows out of *** cancers can cause serious consequences and deaths.A great progress has been made in cancer research which significantly improved our knowledge to understand the nature and mechanisms of the disease,but the origins of cancer are far from being well understood due to limitations of suitable model systems and to the complexities of the *** view of the fact that the cancers are found in various species of vertebrates and other metazoa,here,we suggest that cancer also occurs in parasitic protozoans such as Trypanosoma brucei,a blood parasite,and Toxoplasma gondii,an obligate intracellular *** treatment,these protozoan cancers may cause severe disease and death in mammals including *** simpler genomes of these single cell organisms,in combination with their complex life cycles and fascinating life cycle differentiation processes,may help us to better understand the origins of cancers,in particular,leukemias.