3D printed titanium scaffolds with ordered TiO2 nanotubular surface and mesoporous bioactive glass for bone repair

作     者：Pengyu Zhao Yaqin Liu Tian Li Yanling Zhou Sander Leeflang Lei Chen Chengtie Wu Jie Zhou Zhiguang Huan 

作者机构：State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Department of Biomechanical Engineering Delft University of Technology 

出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))

年 卷 期：2020年第30卷第4期

页      面：502-509页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 080201[工学-机械制造及其自动化] 

基　　金：the financial support from the National Key Research and Development Program of China (No. 2017YFB1104101) Natural Science Foundation of China (No. 81671830) Science and Technology Commission of Shanghai Municipality (19441902300) Shanghai Nature Science Foundation (19ZR1464800) 

主　　题：Titanium Scaffold Mesoporous bioactive glass Nanotube Anodization 

摘      要：Titanium alloy scaffolds have recently gained substantial interest for the treatment of critical-size bone defect,particularly along with the maturity of the 3D printing technology that is capable of turning scaffold design ideas into real implants. As titanium alloys lack surface osteogenic activity, for improved biological performance of such scaffolds, surface modification is necessary. Various coating materials and coating methods have been explored. In this study, we developed a unique surface modification method to provide the surface of 3D printed titanium scaffolds with nano-sized structure and bioactive agent. Uniform, ordered TiO2nanotube arrays were formed by applying two-step anodization, and then mesoporous bioactive glass（MBG） was loaded into nanotubes. The results of in vitro immersion testing showed that bioactive ions, i.e., Si and Ca ions, could be steadily and continuously released from MBG into basal medium. The assessment of the responses of h BMSCs confirmed that the surface-modified scaffolds supported the adhesion and proliferation of h BMSCs, indicating good surface cytocompatibility. The developed method of combining surface nanostructure and bioactive agent could be used as a new strategy to improve the osteogenic activity of 3D printed titanium alloy scaffolds.