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Craniofacial therapy:advanced local therapies from nano-engineered Titanium implants to treat craniofacial conditions

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International Journal of Oral Science 2023年第1期15卷 33-49页

作者： Karan Gulati Chengye Ding Tianqi Guo Houzuo Guo Huajie Yu Yan Liu The University of Queensland School of DentistryHerstonQLDAustralia Laboratory of Biomimetic Nanomaterials Department of OrthodonticsPeking University School and Hospital of StomatologyBeijingChina National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials BeijingChina Department of Oral Implantology Peking University School and Hospital of StomatologyBeijingChina Fourth Clinical Division Peking University School and Hospital of StomatologyBeijingChina

Nano-engineering-based tissue regeneration and local therapeutic delivery strategies show significant potential to reduce the health and economic burden associated with craniofacial defects,including traumas and tumours.Critical to the success of such nano-engineered non-resorbable craniofacial implants include load-bearing functioning and survival in complex local trauma conditions.Further,race to invade between multiple cells and pathogens is an important criterion that dictates the fate of the implant.In this pioneering review,we compare the therapeutic efficacy of nano-engineered Titanium-based craniofacial implants towards maximised local therapy addressing bone formation/resorption,soft-tissue integration,bacterial infection and cancers/tumours.We present the various strategies to engineer Titanium-based craniofacial implants in the macro-,micro-and nano-scales,using topographical,chemical,electrochemical,biological and therapeutic modifications.A particular focus is electrochemically anodised Titanium implants with controlled nanotopographies that enable tailored and enhanced bioactivity and local therapeutic release.Next,we review the clinical translation challenges associated with such implants.This review will inform the readers of the latest developments and challenges related to therapeutic nano-engineered craniofacial implants.

关键词： implants Titanium local

Effect of Titanium on the sticking of pellets based on hydrogen metallurgy shaft furnace:Behavior analysis and mechanism evolution

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 282-291页

作者： Jinge Feng Jue Tang Zichuan Zhao Mansheng Chu Aijun Zheng Xiaobing Li Xiao’ai Wang School of Metallurgy Northeastern UniversityShenyang 110819China Institute for Frontier Technologies of Low-carbon Steelmaking Northeastern UniversityShenyang 110819China Liaoning Low-carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education Shenyang 110819China Zhang Xuan Technology of HBIS Group Co. Ltd.Shijiazhuang 050000China Xuanhua Iron and Steel Group Co. Ltd.Shijiazhuang 050000China Iron and Steel Research Institute of HBIS Group Co. Ltd.Shijiazhuang 050000China

Direct reduction based on hydrogen metallurgical gas-based shaft furnace is a promising technology for the efficient and low-carbon smelting of vanadium-Titanium magnetite.However,in this process,the sticking of pellets occurs due to the aggregation of metal-lic iron between the contact surfaces of adjacent pellets and has a serious negative effect on the continuous operation.This paper presents a detailed experimental study of the effect of TiO2 on the sticking behavior of pellets during direct reduction under different conditions.Results showed that the sticking index(SI)decreased linearly with the increasing TiO2 addition.This phenomenon can be attributed to the increase in unreduced FeTiO3 during reduction,leading to a decrease in the number and strength of metallic iron interconnections at the sticking interface.When the TiO2 addition amount was raised from 0 to 15wt%at 1100°C,the SI also increased from 0.71%to 59.91%.The connection of the slag phase could be attributed to the sticking at a low reduction temperature,corresponding to the low sticking strength.Moreover,the interconnection of metallic iron became the dominant factor,and the SI increased sharply with the increase in re-duction temperature.TiO2 had a greater effect on SI at a high reduction temperature than at a low reduction temperature.

关键词： Titanium sticking index hydrogen metallurgy direct reduction pellets

Integrated high-performance and accurate shaping technology of low-cost powder metallurgy Titanium alloys: A comprehensive review

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 413-426页

作者： Xuemeng Gan Shaofu Li Shunyuan Xiao Yafeng Yang State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Science and Technology on Particle Materials Chinese Academy of SciencesBeijing 100190China

The practical engineering applications of powder metallurgy (PM) Ti alloys produced through cold compaction and pressure-less sintering are impeded by poor sintering densification, embrittlement caused by excessive O impurities, and severe sintering deforma-tion resulting from the use of heterogeneous powder mixtures. This review presents a summary of our previous work on addressing the above challenges. Initially, we proposed a novel strategy using reaction-induced liquid phases to enhance sintering densification. Near- complete density (relative density exceeding 99%) was achieved by applying the above strategy and newly developed sintering aids. By focusing on the O-induced embrittlement issue, we determined the onset dissolution temperature of oxide films in the Ti matrix. On the basis of this finding, we established a design criterion for effective O scavengers that require reaction with oxide films before their dissol-ution. Consequently, a ductile PM Ti alloy was successfully obtained by introducing 0.3wt% NdB6 as the O scavenger. Lastly, a powder- coating strategy was adopted to address the sintering deformation issue. The ultrafine size and shell-like distribution characteristics of coating particles ensured rapid dissolution and homogeneity in the Ti matrix, thereby facilitating linear shrinkage during sintering. As a result, geometrically complex Ti alloy parts with high dimensional accuracy were fabricated by using the coated powder. Our fundament-al findings and related technical achievements enabled the development of an integrated production technology for the high-performance and accurate shaping of low-cost PM Ti alloys. Additionally, the primary engineering applications and progress in the industrialization practice of our developed technology are introduced in this review.

关键词： powder metallurgy Titanium sintering densification oxygen scavenging accurate shaping

Lead-free perovskite Cs_(2)AgBiBr_(6)photodetector detecting NIR light driven by Titanium nitride plasmonic hot holes

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Photonics Research 2024年第3期12卷 522-533页

作者： ZIJIAN LIU YUYING XI WENBO ZENG TING JI WENYAN WANG SITONG GUO LINLIN SHI RONG WEN YANXIA CUI GUOHUI LI College of Physics College of Electronic Information and Optical EngineeringKey Laboratory of Advanced Transducers and Intelligent Control System of Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Lead-free perovskite Cs_(2)AgBiBr_(6)manifests great potential in developing high-performance,environmentally friendly,solution-processable photodetectors(PDs).However,due to the relatively large energy bandgap,the spectrum responses of Cs_(2)AgBiBr_(6)PDs are limited to the ultraviolet and visible region with wavelengths shorter than 560 nm.In this work,a broadband Cs_(2)AgBiBr_(6)PD covering the ultraviolet,visible,and near infrared(NIR)range is demonstrated by incorporating Titanium nitride(TiN)nanoparticles that are prepared with the assistance of self-assembled polystyrene sphere array.In addition,an atomically thick Al2O3layer is introduced at the interface between the Cs_(2)AgBiBr_(6)film and TiN nanoparticles to alleviate the dark current deterioration caused by nanoparticle incorporation.As a result,beyond the spectrum range where Cs_(2)AgBiBr_(6)absorbs light,the external quantum efficiency(EQE)of the TiN nanoparticle incorporated Cs_(2)AgBiBr_(6)PD is enhanced significantly compared with that of the control,displaying enhancement factors as high as 2000 over a broadband NIR wavelength range.The demonstrated enhancement in EQE arises from the photocurrent contribution of plasmonic hot holes injected from TiN nanoparticles into Cs_(2)AgBiBr_(6).This work promotes the development of broadband solution-processable perovskite PDs,providing a promising strategy for realizing photodetection in the NIR region.

关键词： perovskite Titanium ultraviolet

Fracture behaviors of commercially pure Titanium under biaxial tension:Experiment and modeling

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Journal of Materials Science & Technology 2023年第9期140卷 176-186页

作者： Jin-Kui Meng Li Liu Jian-Tang Jiang Guo Huang Liang Zhen School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China National Key Laboratory of Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

The fracture behaviors and associated mechanisms of metallic materials under biaxial stress are vital for their manufacturability and service performance.In this work,the fracture behaviors of commercially pure Titanium(CP-Ti)under quasi-uniaxial and equi-biaxial tension were investigated by using the digital image correlation technique and finite element modeling.The fracture behaviors under quasi-uniaxial tension were characterized by a general normal fracture.In contrast,normal fracture firstly occurred per-pendicular to the rolling direction(RD)under equi-biaxial tension,followed by secondary shear fracture along the 45°direction relative to the RD.The normal fracture was attributed to the lower strain hard-ening ability in RD compared to the transverse direction(TD)induced by the TD-split type basal texture.The different hardening abilities introduced large shear stress in the 45°direction,which contributed sig-nificantly to the secondary shear fracture.An anisotropy parameter K(△S_(s)/σ_(s)),defined as the ratio of the equivalent effective traction stress to the yield strength,was proposed for the first time,to predict the fracture path with the impact of crystallographic preferred orientation.

关键词： Titanium Biaxial tension Fracture behavior Digital image correlation(DIC)technique Finite element modeling

Current situation and development trend of Titanium metal industry in China

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 599-610页

作者： Guanzhou Qiu Yufeng Guo School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

Titanium metal and alloy are key materials for technological development,which significantly promote the development of the hightech economy in China.The consumption of high-end Titanium materials and the developmental level of the Titanium industry are important indexes of a country’s comprehensive power.However,at present,the application amount and level of high-end Titanium materials in China are limited by many factors,including the dependence of raw materials on imports,high processing cost,and structural imbalance of products.Based on the characteristics of Titanium resources and the current situation of the Titanium industry,the whole Titanium industrial chain in China should be updated.Improving the quality of raw materials is important to produce low-cost,high-end Titanium materials using Titanium resources with high calcium and magnesium contents in the Panxi region.In addition,the steel-Titanium joint production is a vital step to reduce the processing cost of Titanium materials.Moreover,the consumption structure of Titanium materials should be completed to expand their application.Gradually implementing these suggestions,the overall level of China’s Titanium industry will be greatly improved,thereby rapidly establishing an advanced scientific and technological country.

关键词： Titanium Titanium resources prodcution cost high-end Titanium material steel-Titanium joint prodcution

Constructions of ROS-responsive Titanium-hydroxyapatite implant for mesenchymal stem cell recruitment in peri-implant space and bone formation in osteoporosis microenvironment

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Bioactive Materials 2022年第12期7卷 56-71页

作者： Maohua Chen Yuting Sun Yanhua Hou Zhong Luo Menghuan Li Yujia Wei Maowen Chen Lu Tan Kaiyong Cai Yan Hu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing400044China School of Life Science Chongqing UniversityChongqing400044China Chongqing Engineering Research Center of Pharmaceutical Science Chongqing Medical and Pharmaceutical CollegeChongqing401331China

To solve the issue of unsatisfactory recruitment of mesenchymal stem cells(MSCs)around implant in osteoporotic fractures,we fabricated a ROS-responsive system on Titanium surface through hydroxyapatite coating and biomolecule grafting.The porous hydroxyapatite and phosphorylated osteogenic growth peptides(p-OGP)were introduced onto Titanium surface to synergistically improve osteogenic differentiation of MSCs.After the p-OGPpromoted expression of osteogenic related proteins,the calcium and phosphate ions were released through the degradation of hydroxyapatite and integrated into bone tissues to boost the mineralization of bone matrix.The ROS-triggered release of DNA aptamer(Apt)19S in the osteoporotic microenvironment guides MSC migration to implant site due to its high affinity with alkaline phosphatase on the membrane of MSCs.Once MSCs reached the implant interface,their osteogenic differentiation potential was enhanced by p-OGP and hydroxyapatite to promote bone regeneration.The study here provided a simple and novel strategy to prepare functional Titanium implants for osteoporotic bone fracture repair.

关键词： Mesenchymal stem cell recruitment Osteogenic differentiation Hydroxyapatite Titanium Osteoporosis

Two-stage cyclic ammonium sulfate roasting and leaching of extracting vanadium and Titanium from vanadium slag

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Chinese Journal of Chemical Engineering 2022年第7期35卷 39-47页

作者： Qing Lin Guoquan Zhang Kun Wang Dongmei Luo Siyang Tang Hairong Yue School of Chemical Engineering Sichuan UniversityChengdu 610065China

Compared with traditional sodium or calcification roasting process for vanadium extraction from raw vanadium slag(V-slag),ammonium sulfate(AS)roasting could reduce about 470℃ roasting temperature and avoid Cl_(2),HCl,sodium-containing waste-water and waste gypsum discharging.To reduce the amount of AS added in vanadium extraction process,an efficient AS two-stage cyclic roasting and acid leaching process was proposed.The result of TG analysis indicates V-slag could be decomposed in 275-380℃ using AS roasting process.Using 2.03:1 total mass ratio of AS to V-slag,90.86%V and 80.54%Ti could be extracted after 380℃ roasting for 30 min and 8%initial concentration of H_(2)SO_(4) leaching at 70℃ for 100 min.XRD analysis indicates V-containing spinel phase in the 1st stage leaching residue would be efficiently decomposed by the cyclic two-stage roasting and leaching process.Furthermore,the valence of V(Ⅲ)in raw V-slag was not changed after the 1st AS roasting stage,but a part of V(Ⅲ)in the 1st leaching residue was oxidized to V(V)after 2nd roasting process.

关键词： Vanadium Titanium Roasting Leaching

Regulation of the Macrophage Phenotype on Titanium Metal by Surface Modification

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Journal of Bionic Engineering 2022年第6期19卷 1625-1636页

作者： Shibing Xiong Xugang Lu Rui Zuo Ping Huang Bangcheng Yang Engineering Research Center in Biomaterials Sichuan UniversityChengdu610064China National Engineering Research Center for Biomaterials Chengdu610064China Sichuan Guojia Biomaterials Co. LtdChengdu610064China Panzhihua University Panzhihua Int Res Inst Vanadium and TitaniumPanzhihua617000SichuanChina

The regulation of macrophage phenotype(M1/M2)is very important for tissue repair.The macrophage phenotypes could be affected by the physical and chemical parameters of implant surface.The aim of this study was to investigate the effects of surface modifications of Titanium metals on macrophage phenotype.The medical pure Titanium metals(PT-Ti)subjected to Anodic Oxidation(AO-Ti),Sand Blasting/acid etching(SLA-Ti)and Plasma-sprayed HA coating(HA coating-Ti)were used for regulating the phenotype of macrophage.The results showed that the Raw264.7 cells of AO-Ti groups had no obvious pseudopodia and could spread evenly in all directions.The levels of IL-1βand TNF-α,which belong to pro-inflammatory genes,expressed by the cells on AO-Ti groups were the lowest among all of the modified Titanium groups.But,the levels of IL-10 and TGF-β,which belong to anti-inflammatory genes,expressed on AO-Ti groups were much higher than those on the other groups.Furthermore,the AO-Ti could regulate the expression of SOCS-1 and SOCS-3 to affect the active of NF-κB signaling.The gene expression results of macrophages showed that the AO-Ti was more conductive to inhibit the expression of M1-related genes and promote the expression of M2-related genes in an inflammatory environment.The AO-Ti was more beneficial to tissue repair than other modified Titanium metals.The results showed that the anodic oxidation is an effective method to regulate the phenotype of macrophages.

关键词： Titanium Dental implant Bionic surface modification Anti-inflammatory Macrophage phenotype