Mitochondrial integrity in neuronal injury and repair

作     者：Qi Han Xiao-Ming Xu Qi Han;Xiao-Ming Xu

作者机构：Spinal Cord and Brain Injury Research GroupStark Neurosciences Research Institute Department of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第4期

页      面：674-675页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：This work was supported by NIH 1R01100531,1R01 NS103481 Merit Review Award I01 BX002356,I01 BX003705,I01 RX002687 from the U.S.Department of Veterans Affairs. 

主　　题：thereby metabolism distribute 

摘      要：The mitochondrion is the powerhouse of a cell.As the principal subcellular organelles that mediate adenosine triphosphate(ATP)production and calcium buffering,mitochondria actively distribute to areas of high energy demand and calcium flux.The highly polarized nerve cells in the central nervous system(CNS),which have unparalleled size and complexity and long-projection axons,are cells with high-energy requirements.Mitochondria are regionally organized within these neurons,with higher accumulations in the soma,the hillock,the nodes of Ranvier,and the axon terminals.In the synaptic region,mitochondria regulate calcium and ATP levels,thereby maintaining synaptic transmission and structure.Defects in mitochondrial dynamics can cause deficits in neuronal transport,transmission,and metabolism(Misgeld and Schwarz,2017).