The Sterile 20-Like Kinase Tao Controls Tissue Homeostasis by Regulating the Hippo Pathway in Drosophila Adult Midgut

作     者：Xudong Huang Lai Shi Jun Cao Fangfei He Renling Li Yan Zhang Shuang Miao Longjin Jin Jia Qu Zhouhua Li Xinhua Lin 

作者机构：School of Optometry and Ophthalmology and Eye HospitalWenzhou Medical University State Key Laboratory of Biomembrane and Membrane BiotechnologyInstitute of ZoologyChinese Academy of Sciences School of Laboratory Medicine and Life ScienceWenzhou Medical University School of Life SciencesCapital Normal University Division of Developmental BiologyCincinnati Children’s Hospital Medical Center 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2014年第41卷第8期

页      面：429-438页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the grants from the National Natural Science Foundation of China (Nos. 31271582 and 31030049) Wenzhou Medical University (No. XNK07005) Research Foundation for Advanced Talents of Wenzhou Medical College (No. QTJ08012) the National Basic Research Program of China (Nos. 2011CB943901, 2011 CB943902 and 2011CB943802) Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDA01010101) 

主　　题：Stem cell Midgut Drosophila Tissue homeostasis Tao Hippo 

摘      要：The proliferation and differentiation of adult stem cells must be tightly controlled in order to maintain resident tissue homeostasis. Dysfunction of stem cells is implicated in many human diseases, including cancer. However, the regulation of stem cell proliferation and differentiation is not fully understood. Here we show that the sterile-like 20 kinase, Tao, controls tissue homeostasis by regulating the Hippo pathway in the Drosophila adult midgut. Depletion of Tao in the progenitors leads to rapid intestinal stem cell （ISC） proliferation and midgut homeostasis loss. Meanwhile, we find that the Janus kinase （JAK）/signal transducer and activator of transcription （STAT） signaling activity and cytokine production are significantly increased, resulting in stimulated ISC proliferation. Furthermore, expression of the Hippo pathway downstream targets, Diapl and bantam, is dramatically increased in Tao knockdown intestines. Consistently, we show that the Yorkie （Yki） acts downstream of Tao to regulate ISC proliferation. Together, our results provide insights into our understanding of the mechanisms of stem cell proliferation and tissue homeostasis control.