Optimization of the Electrospinning Conditions by Box-Behnken Design to Prepare Poly(Vinyl Alcohol)/Chitosan Crosslinked Nanofibers

作     者：Vinícius R. Viana Willian H. Ferreira Edwin G. Azero Marcos L. Dias Cristina T. Andrade 

作者机构：Instituto de Macromoléculas Professora Eloisa Mano Universidade Federal do Rio de Janeiro Centro de Tecnologia Bloco J Rio de Janeiro Brazil Departmento de Ciências Naturais Universidade Federal do Estado do Rio de Janeiro Avenida Pasteur Rio de Janeiro Brazil 

出 版 物：《Journal of Materials Science and Chemical Engineering》 (材料科学与化学工程（英文）)

年 卷 期：2020年第8卷第4期

页      面：13-31页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

主　　题：Electrospinning Poly(Vinyl Alcohol) Chitosan Box-Behnken Design 

摘      要：Electrospun poly(vinyl alcohol)/chitosan nanofibers had their solution and process parameters optimized using a Box-Behnken design and desirability function. Four factors (applied voltage, flow rate, distance tip-to-plate and amount of chitosan) were varied to produce electrospun mats with a low fiber diameter. An empirical model was developed for each response using response surface methodology (RSM), which revealed that flow rate had no significant influence on the assessed responses. With desirability function, the optimal conditions to produce the nanofibers were applied voltage of 13.1 kV, 30% chitosan concentration and distance tip-to-plate of 10 cm. The fiber diameter and standard deviation were 196.5 ± 28.3 nm, compared to the predicted values of 185.9 ± 26.8 nm. The desirability function allied with Box-Benhken design proved themselves important tools to predict process parameters for the development of nanofibers. The mats were crosslinked with glutaraldehyde for 24 h and 48 h and presented good water stability and enhanced mechanical properties.