ROS does not contribute to acute development of nitroglycerine tolerance in rat aortas

作     者：WONG SL DOING JH LEE HK LEE WY LAU CW 

作者机构：Institute of Vascular Medicine and School of Biomedical Sciences Departments of Chemistry and PharmacyChinese University of Hong Kong 

出 版 物：《中国病理生理杂志》 (Chinese Journal of Pathophysiology)

年 卷 期：2010年第26卷第A10期

页      面：2065-2066页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by CUHK Focused Investment scheme 

主　　题：explain limits xanthine impaired contraction incubation relaxation exposed inhibited markedly 

摘      要：The development of nitroglycerine tolerance limits its clinical efficacy of nitric oxide(NO)donors. Several cellular mechanisms have been proposed to explain this phenomenon,one of which is an exaggerated production of reactive oxygen specious(ROS).The present study examined whether ROS contribute to the occurrence of nitroglycerine tolerance which is induced