Association of angiotensin Ⅱ type 1 receptor gene polymorphism with essential hypertension

作     者：蒋珍妮 赵文胜 俞锋 徐耕 JIANG Zhenni;YU Feng;XU Geng;ZHAO Wensheng

作者机构：浙江大学医学院附属第二医院心内科杭州310009 浙江大学医学院附属第一医院麻醉科杭州310006 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2001年第114卷第12期

页      面：17-19,101-102页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：essential  hypertension  ·  angiotensin Ⅱ  ·  receptor    ·   gene  polymorphism 

摘      要：Objective To determine whether the polymorphism A1166C in the angiotensin Ⅱ type 1 receptor (AT1R) gene is associated with essential hypertension Methods A casecontrol study was carried out using 125 hypertensive and 103 normotensive subjects The AC variant at position 1166 (A1166C) of the AT 1R gene was identified by polymerase chain reaction (PCR) and PCR/restriction fragment length polymorphism (PCR/RFLP) analysis The digestion products were separated on 2% agarose gels and visualized with ethidium bromide under ultraviolet ray Results The differences in C1166 allele frequency and in the AC genotype distribution of the AT 1R gene between the hypertensive and normotensive groups were statistically significant (C allele: 0.092 vs 0.034, χ2=6.1.86,P0.05; AC genotype: 0.184 vs 0.068, χ2=6.654,P0.05) Conclusion The AC genotype is associated with essential hypertension, and the C allele may be a marker for predisposition to hypertension in Chinese Han population