Livestock breeding for the 21st century: the promise of the editing revolution

作     者：Chris PROUDFOOT Gus MCFARLANE Bruce WHITELAW Simon LILLICO Chris PROUDFOOT;Gus MCFARLANE;Bruce WHITELAW;Simon LILLICO

作者机构：The Roslin Institute and Royal(Dick)School of Veterinary StudiesUniversity of EdinburghEaster BushMidlothianEH259RGUK 

出 版 物：《Frontiers of Agricultural Science and Engineering》 (农业科学与工程前沿（英文版）)

年 卷 期：2020年第7卷第2期

页      面：129-135页

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 0905[农学-畜牧学] 08[工学] 0906[农学-兽医学] 09[农学] 071007[理学-遗传学] 0836[工学-生物工程] 090501[农学-动物遗传育种与繁殖] 

基　　金：BBSRC [BB/M028313/1  BB/L007371/1  BB/N015339/1  BBS/E/D/10002071  BBS/E/D/30002276  BBS/E/D/20221658  BB/P003966/1  BB/M018342/1] Funding Source: UKRI 

主　　题：cattle pig sheep chicken aquaculture CRISPR 

摘      要：In recent years there has been a veritable explosion in the use of genome editors to create sitespecific changes,both in vitro and in vivo,to the genomes of a multitude of species for both basic research and ***,which form a vital component of most societies,are no *** selective breeding has been hugely successful at enhancing some production traits,the rate of progress is often slow and is limited to variants that exist within the breeding *** editing provides the potential to move traits between breeds,in a single generation,with no impact on existing productivity or to develop de novo phenotypes that tackle intractable issues such as *** such,genome editors provide huge potential for ongoing livestock development programs in light of increased demand and disease *** review will highlight some of the more notable agricultural applications of this technology in livestock.