Herbal extracts counteract cisplatin-mediated cell death in rat testis
Herbal extracts counteract cisplatin-mediated cell death in rat testis作者机构：Biology Department United Arab Emirates University AI-Ain 17551 United Arab Emirates Hematology Laboratory Twain Hospital At-Ain 15258 United Arab Emirates Histopathology Laboratory Twain Hospital At-Ain 15258 United Arab Emirates
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2008年第10卷第2期
页 面：291-297页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：cisplatin cell death toxicity flow cytometry ginger roselle
摘 要：Aim： To evaluate the protective effects of ginger （Gin） and roselle （Ros） against testicular damage and oxidative stress in a cisplatin （CIS）-induced rodent model. Their protective effects against CIS-induced apoptosis in testicular and epididymal sperms is also investigated. Methods： Ethanol extracts of Gin or Ros （1 g/***） were given orally to male albino rats for 26 days. This period began 21 days before a single CIS intraperitoneal injection （10 mg/kg body weight）. Results： Gin or Ros given orally significantly restored reproductive function. Both tested extracts notably reduced the CIS-induced reproductive toxicity, as evidenced by restoring the testis normal morphology. In Gin and Ros, the attenuation of CIS-induced damage was associated with less apoptotic cell death both in the testicular tissue and in the sperms. CIS-induced alterations of testicular lipid peroxidation were markedly improved by these plant extracts. Conclusion： The present results provide further insights into the mechanisms of protection against CIS-induced reproductive toxicity and confirm the essential anti-oxidant potential of both examined extracts. （Asian J Androl 2008 Mar; 10： 291-297）
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