Clinical relevance of increased serum preneoplastic antigen in hepatitis C-related hepatocellular carcinoma

作     者：Satoyoshi Yamashita Akira Kato Toshitaka Akatsuka Takashi Sawada Tomohide Asai Noriyuki Koyama Kiwamu Okita 

作者机构：Department of Gastroenterology and HepatologyJapan Community Health Care Organization Shimonoseki Medical CenterShimonosekiYamaguchi 7500061Japan Department of PhysiologyFaculty of MedicineSaitama Medical UniversityIruma-gunSaitama 3500495Japan Research and Development DivisionSekisui Medical Company LimitedRyugasakiIbaraki 3010852Japan Clinical Research DepartmentEidia Company LimitedChiyoda-kuTokyo 1010032Japan Eisai Company LimitedShinjuku-kuTokyo 1600812Japan Department of Internal MedicineShunan Memorial HospitalKudamatsuYamaguchi 7440033Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第13期

页      面：1463-1473页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Serum preneoplastic antigen Hepatitis C virus Hepatocellular carcinoma Des-γ-carboxy-prothrombin α-Fetoprotein Sensitivity Specificity 

摘      要：BACKGROUND The prognosis of hepatocellular carcinoma(HCC)patients remains poor despite advances in treatment modalities and *** is important to identify useful markers for the early detection of HCC in *** antigen(PNA),originally reported in a rat carcinogenesis model,is increased in the tissues and serum of HCC *** To determine the diagnostic value of PNA for discriminating HCC and to characterize PNA-positive *** Patients with hepatitis C virus(HCV)-related hepatic disorders were prospectively enrolled in this study,which included patients with hepatitis,with cirrhosis,and with HCC.A novel enzyme-linked immunosorbent assay was developed to measure serum PNA concentrations in *** Serum PNA concentrations were measured in 89 controls and 141 patients with HCV infections(50 hepatitis,44 cirrhosis,and 47 HCC).Compared with control and non-HCC patients,PNA was increased in *** receiver operating characteristic curve analysis,the sensitivity of PNA was similar to the HCC markers des-γ-carboxy-prothrombin(DCP)andα-fetoprotein(AFP),but the specificity of PNA was *** was no correlation between PNA and AFP and a significant but weak correlation between PNA and DCP in HCC ***,the correlations with biochemical markers were completely different for PNA,AFP,and DCP;glutamyl transpeptidase was highly correlated with PNA,but not with AFP or DCP,and was significantly higher in PNA-high patients than in PNA-low patients with HCV-related *** PNA may have the potential to diagnose a novel type of HCC in which glutamyl transpeptidase is positively expressed but AFP or DCP is weakly or negatively expressed.