Genome-wide detection of selective signatures in a Jinhua pig population

作     者：XU Zhong SUN Hao ZHANG Zhe Zhao Qing-bo Babatunde Shittu Olasege Li Qiu-meng Yue Yang Ma Pei-pei Zhang Xiang-zhe Wang Qi-shan Pan Yu-chun XU Zhong;SUN Hao;ZHANG Zhe;ZHAO Qing-bo;Babatunde Shittu OLASEGE;LI Qiu-meng;YUE Yang;MA Pei-pei;ZHANG Xiang-zhe;WANG Qi-shan;PAN Yu-chun

作者机构：Department of Animal ScienceSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240P.R.China Shanghai Key Laboratory of Veterinary Bio-technologyShanghai 200240P.R.China 

出 版 物：《Journal of Integrative Agriculture》 (农业科学学报（英文版）)

年 卷 期：2020年第19卷第5期

页      面：1314-1322页

核心收录：

学科分类：0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖] 

基　　金：supported by the Key Technology R&D Program of China(2016C02054-2) the National Natural Science Foundation of China(31872976) 

主　　题：pig genome selection signatures extended haplotype homozygosity(EHH) candidate genes 

摘      要：The aim of this study was to detect evidence for signatures of recent selection in the Jinhua pig *** results can be useful to better understand the regions under selection in Jinhua pigs and might shed some lights on groups of genes that control production *** the present study,we performed extended haplotype homozygosity(EHH)tests to identify significant core regions in 202 Jinhua pigs.A total of 26161 core regions spanning 636.42 Mb were identified,which occupied approximately 28%of the genome across all autosomes,and 1158 significant(P0.01)core haplotypes were *** in these regions were related to several economically important traits,including meat quality,reproduction,immune responses and exterior traits.A panel of genes including ssc-mir-365-2,KDM8,RABEP2,GSG1L,RHEB,RPH3AL and a signal pathway of PI3K-Akt were detected with the most extreme *** findings in our study could draw a comparatively genome-wide map of selection signature in the pig genome,and also help to detect functional candidate genes under positive selection for further genetic and breeding research in Jinhua and other pigs.