Intracoronary pressure gradient measurement in acute myocardial infarction patients with the no-reflow phenomenon during primary percutaneous coronary intervention

作     者：Ming-Dong Gao En-Yuan Zhang Yuan-Ying Liu Xiao-Wei Li Jian-Yong Xiao Gen-Yi Sun Yin Liu Gao Ming-Dong;Zhang En-Yuan;Liu Yuan-Ying;Li Xiao-Wei;Xiao Jian-Yong;Sun Gen-Yi;Liu Yin

作者机构：Department of Coronary Care UnitTianjin Chest HospitalTianjin 300222China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2020年第133卷第7期

页      面：766-772页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by a grant from the Major Engineering Projects from Tianjin Science and Technology Committee(No.16ZXMJSY00150) 

主　　题：Acute myocardial infarction Coronary hemodynamics Intracoronary pressure gradient No-reflow Primary percutaneous coronary intervention 

摘      要：Background:Various experimental and clinical studies have reported on coronary microcirculatory dysfunction(no-reflowphenomenon).Nevertheless,pathogenesis and effective treatment are yet to be fully *** study aimed to measure the intracoronary pressure gradient in the no-reflow artery during emergent percutaneous coronary intervention and explore the potential mechanism of ***:From September 1st,2018 to June 30th,2019,intracoronary pressure in acute myocardial infarction patient was continuously measured by aspiration catheter from distal to proximal segment in the Department of Coronary Care Unit,Tianjin Chest Hospital,respectively in no-reflow arteries(no-reflow group)and arteries with thrombolysis in myocardial infarction-3 flow(control group).At least 12 cardiac cycles were consecutively recorded when the catheter was pulled *** forward systolic pressure gradient was calculated as proximal systolic pressure minus distal systolic *** between groups was made using the Student t test,Mann-Whitney U-test or Chi-square test,as ***:Intracoronary pressure in 33 no-reflow group and 26 in control group were *** intracoronary forward systolic pressure gradient was-1.3(-4.8,0.7)and 3.8(0.8,8.8)mmHg in no-reflow group and control group(Z=-3.989,P0.001),respectively,while the forward diastolic pressure gradient was-1.0(-3.2,0)and 4.6(0,16.5)mmHg in respective groups(Z=-3.851,P0.001).Moreover,the intracoronary forward pressure gradient showed significant difference between that before and after nicorandil medication(Z=-3.668,P0.001 in systolic pressure gradient and Z=-3.530,P0.001 in diastolic pressure gradient).Conclusions:No reflow during emergent coronary revascularization is significantly associated with local hemodynamic abnormalities in the coronary *** nicorandil administration at the distal segment of a coronary artery with an aspiration catheter could improve the microcir