Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys

作     者：Shi Jin Dan Zhang Xiaopeng Lu Yang Zhang Lili Tan Ying Liu Qiang Wang Shi Jin;Dan Zhang;Xiaopeng Lu;Yang Zhang;Lili Tan;Ying Liu;Qiang Wang

作者机构：School and Hospital of StomatologyChina Medical UniversityShenyang 110001China Liaoning Provincial Key Laboratory of Oral DiseasesShenyang 110001China Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shenyang National Laboratory for Materials ScienceNortheastern UniversityShenyang 110819China School of StomatologyJiamusi UniversityJiamusi 154007China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2020年第47卷第12期

页      面：190-201页

核心收录：

学科分类：0817[工学-化学工程与技术] 0806[工学-冶金工程] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0802[工学-机械工程] 0801[工学-力学（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：financially supported by the National Natural Science Foundation of China(No.U1737102) the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(No.2017QNRC001) the Shenyang Key R&D and Technology Transfer Program(No.Z18-0-027) the Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement(Nos.2016YFC1101804 and 2016YFC1100604) 

主　　题：Magnesium Mg-Zn-Zr-Nd alloy Mg-Zn-Zr-Y alloy Biodegradable implant Biocompatibility 

摘      要：Biodegradable magnesium alloys have been turned out to be a promising candidate for orthopedic *** this study,the mechanical properties,degradation behaviorand cytocompatibility of MgZn-Zr-Nd and Mg-Zn-Zr-Y alloys were studied in comparison with pure *** tests showed that the strength and ductility of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were *** corrosion resistance analyzed by electrochemical test and immersion test in alpha modified eagle(α-MEM) medium with 10% fetal bovine serum(FBS) revealed the degradation of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were faster than pure Mg at an early stage but slowed down after long time *** metal ion concentrations were consistent with the corrosion ***-Zn-Zr-Nd alloy shows better mechanical properties than pure Mg and better corrosion resistance than Mg-Zn-Zr-Y *** direct and indirect in vitro tests with MC3 T3-E1 cells demonstrate that Mg-Zn-Zr-Nd shows the best cytocompatibility and *** results suggest that Mg-Zn-Zr-Nd alloy shows an ideal combination of mechanical,corrosive and biological *** summary,these results implying the Mg-Zn-Zr-Nd alloy has great potential to benefit the future development of orthopedic applications.