Suppression of Radioactive Strontium Absorption by Sodium Alginate in Animals and Human Subjects

作     者：GONG YIFENG, HUANG ZHAOJIAN, QIANG MEIYU, LAN FUXING,BAI GUANG, MAO YIXIAN MA XlNPEl AND ZHANG FENGGE The Institute of Radiation Medicine, Beijing, China and The Institute of Atomic Energy, Beijing, China 

作者机构：Institute of Radiation Medicine Beijing China. 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：1991年第4卷第3期

页      面：273-282页

核心收录：

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

主　　题：Suppression of Radioactive Strontium Absorption by Sodium Alginate in Animals and Human Subjects 

摘      要：The effect of 23 sodium alginate preparations from different species of algae (Sargassum sp.) and kelp (Laminaria sp.) on reducing the absorption of strontium was studied in detail. A pilot production procedure has been established. Na alginate from S. siliquastrum was proven to be a potent agent for reducing Sr absorption, with high efficiency and virtually no toxicity. It reduced the body burden of strontium 3.3-4.2 fold in rats. Strontium absorption in human subjects was reduced by 78% ( ±8.9) or completely suppressed the increase of serum Sr at 2 h after ingestion of stable Sr in volunteers and decrease 24 h urine Sr to similar extent. No undesirable effects on gastrointestinal function was observed nor were Ca, Fe, Cu and Zn metabolism changed, both in the animal experiments and in human. It was concluded that alginate preparations derived from Sargassum species are a suitable antidote against radiostrontium absorption on a long-term basis, when added to bread at a 6% level. In cases of emergency, an alginate syrup preparation appears to be more suitable because of its rapid action.