The short-chain perfluorinated compounds PFBS,PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation

作     者：Shuyu Liu Renjun Yang Nuoya Yin Francesco Faiola Shuyu Liu;Renjun Yang;Nuoya Yin;Francesco Faiola

作者机构：State Key Laboratory of Environmental Chemistry and EcotoxicologyResearch Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and EnvironmentUniversity of Chinese Academy of SciencesBeijing 100049China Wellcome Trust/CRUK Gurdon InstituteDepartment of PathologyUniversity of CambridgeCambridge CB21QNUK 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2020年第32卷第2期

页      面：187-199页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 0713[理学-生态学] 

基　　金：supported by the National Natural Science Foundation of China (Nos.21876197, 21577166, 21707160) the Chinese Academy of Sciences (Nos.XDB14040301, 2930, QYZDJ-SSW-DQC017) the K.C.Wong Education Foundation. 

主　　题：Short-chain perfluorinated compounds Human mesenchymal stem cells(hMSCs) Adipogenesis/osteogenesis Developmental toxicity PFBS/PFBA/PFHxS/PFHxA 

摘      要：Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention.We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids(PFBS,PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell(hMSC) system.Our results demonstrate significant cyto-and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity.Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA.