Adenylate cyclase activator forskolin alleviates intracerebroventricular propionic acid-induced mitochondrial dysfunction of autistic rats

作     者：Sidharth Mehan Saloni Rahi Aarti Tiwari Tarun Kapoor Kajal Rajdev Ramit Sharma Himanshi Khera Sourabh Kosey Umesh Kukkar Rajesh Dudi Sidharth Mehan;Saloni Rahi;Aarti Tiwari;Tarun Kapoor;Kajal Rajdev;Ramit Sharma;Himanshi Khera;Sourabh Kosey;Umesh Kukkar;Rajesh Dudi

作者机构：Department of NeuropharmacologyISF College of PharmacyMogaPunjabIndia Department of PharmacologyRajendra Institute of Technology&SciencesSirsaHaryanaIndia Pharmacology DivisionCSIR-Indian Institute of Integrative MedicineJammuIndia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第6期

页      面：1140-1149页

核心收录：

学科分类：10[医学] 

主　　题：adenylate cyclase ATP autism forskolin mitochondrial dysfunction neuroinflammation oxidative stress propionic acid 

摘      要：Neuronal mitochondrial dysfunction increases inflammatory mediators and leads to free radical generation and anti-oxidant enzymatic alterations,which are major neuropathological hallmarks responsible for *** dysfunction in autism is associated with decreased ATP levels due to reduced levels of cyclic adenosine *** models of autism were established by intracerebroventricular injection of propionic *** rat models had memory dysfunction,decreased muscle coordination and gait *** estimation of propionic acid-treated rats showed changes in enzyme activity in neuronal mitochondrial electron transport chain complexes and increases in pro-inflammatory cytokines,oxidative stress and lipid *** administration of 10,20 and 30 mg/kg adenylate cyclase activator forskolin for 15 days reversed these changes in a dose-dependent *** findings suggest that forskolin can alleviate neuronal mitochondrial dysfunction and improve neurological symptoms of rats with *** study was approved by the RITS/IAEC,SIRSA,HARYANA on March 3,2014(approval ***/IAEC/2014/03/03).