Astrocytic modulation of potassium under seizures

作     者：Fushun Wang Xiaoming Qi Jun Zhang Jason HHuang Fushun Wang;Xiaoming Qi;Jun Zhang;Jason H. Huang

作者机构：Department of NeurosurgeryBaylor Scott&White HealthTempleTXUSA Institute of Brain and Psychological ScienceSichuan Normal UniversityChengduSichuan ProvinceChina Department of NeurosurgeryPLA General HospitalBeijingChina Department of SurgeryTexas A&M University College of MedicineTempleTXUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第6期

页      面：980-987页

核心收录：

学科分类：10[医学] 

基　　金：supported partially by Helen Vosburg Mc Crillus Plummer Robert Edward Lee Plummer,Jr.Chair in Neurosurgery(to JHH) NIH-R01-NS-067435(to JHH) 

主　　题：AQP4 Ca^2+ signaling cell volume connexins epilepsy K^+ buffering mi RNA NKCC pannexin TBI 

摘      要：The contribution of an impaired astrocytic K^+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade.A defective K^+ regulation leads to an elevated extracellular K^+ concentration([K^+]o).When[K^+]o reaches peaks of 10-12 mM,it is strongly associated with seizure initiation during hypersynchronous neuronal *** the other hand,reactive astrocytes during a seizure attack restrict influx of K^+ across the membrane both passively and *** addition to decreased K^+ buffering,aberrant Ca^2+ signaling and declined glutamate transport have also been observed in astrogliosis in epileptic specimens,precipitating an increased neuronal discharge and induction of *** review aims to provide an overview of experimental findings that implicated astrocytic modulation of extracellular K^+ in the mechanism of epileptogenesis.