Current trends in drug metabolism and pharmacokinetics

作     者：Yuhua Li Qiang Meng Mengbi Yang Dongyang Liu Xiangyu Hou Lan Tang Xin Wang Yuanfeng Lyu Xiaoyan Chen Kexin Liu Ai-Ming Yu Zhong Zuo Huichang Bi 

作者机构：School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510275China The First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of PharmacyDalian Medical UniversityDalian 116044China School of Pharmacythe Chinese University of Hong KongHong KongChina Drug Clinical Trial CenterPeking University Third HospitalBeijing 100191China Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China School of Life SciencesEast China Normal UniversityShanghai 200241China UC Davis School of MedicineSacramentoCA 95817USA 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2019年第9卷第6期

页      面：1113-1144页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100706[医学-药理学] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(grants:81573489,81522047,81730103,81320108027,81660618,and 81773808) the National Key Research and Development Program(grant:2017YFE0109900 and 2017YFC0909303,China) the 111 project(grant:B16047,China) the Key Laboratory Foundation of Guangdong Province(grant:2017B030314030,China) Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093,China) National Engineering and Technology Research Center for New drug Druggability Evaluation(Seed Program of Guangdong Province,2017B090903004,China) Natural Science Foundation of Guangdong(grant:2017A030311018 and 2015A030313124,China) National Institutes of Health(grants No.R01CA225958 and R01GM113888 to Ai-Ming Yu,USA) 

主　　题：Pharmacokinetics Drug metabolism Drug-drug interactions Modeling Metabolizing enzymes Transporters Nuclear receptors Noncoding RNAs 

摘      要：Pharmacokinetics(PK)is the study of the absorption,distribution,metabolism,and excretion(ADME)processes of a *** PK properties is essential for drug development and precision *** this review we provided an overview of recent research on PK with focus on the following aspects:(1)an update on drug-metabolizing enzymes and transporters in the determination of PK,as well as advances in xenobiotic receptors and noncoding RNAs(ncRNAs)in the modulation of PK,providing new understanding of the transcriptional and posttranscriptional regulatory mechanisms that result in inter-individual variations in pharmacotherapy;(2)current status and trends in assessing drug-drug interactions,especially interactions between drugs and herbs,between drugs and therapeutic biologies,and microbiota-mediated interactions:(3)advances in understanding the effects of diseases on PK,particularly changes in metabolizing enzymes and transporters with disease progression;(4)trends in mathematical modeling including physiologically-based PK modeling and novel animal models such as CRISPR/Cas9-based animal models for DMPK studies:(5)emerging non-classical xenobiotic metabolic pathways and the involvement of novel metabolic enzymes,especially *** challenges and perspectives on future directions are discussed,and may stimulate the development of new research models,technologies,and strategies towards the development of better drugs and improved clinical practice.