Osmotic pressure of serum and cerebrospinal fluid in patients with suspected neurological conditions

作     者：Tetsuya Akaishi Toshiyuki Takahashi Ichiro Nakashima Michiaki Abe Masashi Aoki Tadashi Ishii Tetsuya Akaishi;Toshiyuki Takahashi;Ichiro Nakashima;Michiaki Abe;Masashi Aoki;Tadashi Ishii

作者机构：Department of Education and Support for Regional MedicineTohoku University HospitalSendaiJapan Department of NeurologyTohoku University Graduate School of MedicineSendaiJapan Department of NeurologyNational Hospital Organization Yonezawa National HospitalYonezawaJapan Department of NeurologyTohoku Medical and Pharmaceutical UniversitySendaiJapan 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第5期

页      面：944-947页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100204[医学-神经病学] 10[医学] 

基　　金：  (20K07892) 

主　　题：brain parenchyma bulk flow cerebrospinal fluid hydrostatic pressure interstitial fluid osmolarity osmotic pressure 

摘      要：Interstitial fluid movement in the brain parenchyma has been suggested to contribute to sustaining the metabolism in brain parenchyma and maintaining the function of neurons and glial *** pulsatile hydrostatic pressure gradient may be one of the driving forces of this bulk ***,osmotic pressure- related factors have not been studied until *** this prospective observational study,to elucidate the relationship between osmolality (mOsm/kg) in the serum and that in the cerebrospinal fluid (CSF),we simultaneously measured the serum and CSF osmolality of 179 subjects with suspected neurological *** osmolality was 283.6 ± 6.5 mOsm/kg and CSF osmolality was 289.5 ± 6.6 mOsm/*** the specific gravity of serum and CSF is known to be 1.024–1.028 and 1.004–1.007,respectively,the estimated average of osmolarity (mOsm/L) in the serum and CSF covered exactly the same range (i.e.,290.5–291.5 mOsm/L).There was strong correlation between CSF osmolality and serum osmolality,but the difference in osmolality between serum and CSF was not correlated with serum osmolality,serum electrolyte levels,protein levels,or quotient of *** conclusion,CSF osmolarity was suggested to be equal to serum *** is not one of the driving forces of this bulk *** factors such as hydrostatic pressure gradient should be used to explain the mechanism of bulk flow in the brain *** study was approved by the Institutional Review Board of the Tohoku University Hospital (approval *** No.2015-1-257) on July 29,2015.