Biomaterials as carrier, barrier and reactor for cell-based regenerative medicine

作     者：Chunxiao Qi Xiaojun Yan Chenyu Huang Alexander Melerzanov Yanan Du 

作者机构：Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003 China Department of Plastic and Reconstructive Surgery Beijing Tsinghua Changgung Hospital. Medical CenterTsinghua University Beijing 102218 China Cellular and Molecular Technologies Laboratory MIPT Dolgoprudny 141701 Russia 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2015年第6卷第9期

页      面：638-653页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：国家自然科学基金 the Beijing Municipal Natural Science Foundation 

主　　题：carrier barrier reactor biomaterial-assisted therapy regenerative medicine 

摘      要：Cell therapy has achieved tremendous success in regenerative medicine in the past several decades. However, challenges such as cell loss, death and immune-rejection after transplantation still persist. Bio- materials have been designed as carriers to deliver cells to desirable region for local tissue regeneration; as barriers to protect transplanted cells from host immune attack; or as reactors to stimulate host cell recruitment, homing and differentiation. With the assistance of bio- materials, improvement in treatment efficiency has been demonstrated in numerous animal models of degener- ative diseases compared with routine free cell-based therapy. Emerging clinical applications of biomaterial assisted cell therapies further highlight their great pro- mise in regenerative therapy and even cure for complex diseases, which have been failed to realize by conven- tional therapeutic approaches.