Targeting proliferation and survival pathways in head and neck cancer for therapeutic benefit

作     者：Daniel E. Johnson 

作者机构：Departments of Medicine and Pharmacology & Chemical Biology University of Pittsburgh Cancer InstitutePittsburgh Pennsylvania 15213 USA 

出 版 物：《Chinese Journal of Cancer》 (Chin. J. Cancer)

年 卷 期：2012年第31卷第7期

页      面：319-326页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National Institutes ofHealth grants R01 CA137260 and P50 CA097190 

主　　题：治疗效果 头颈部 癌症 存活 增殖 鳞状细胞癌 头部 恶性肿瘤 

摘      要：Head and neck squamous cell carcinomas (HNSCC) are common human malignancies with poor clinical outcomes. The 5-year survival rates for patients with advanced stage HNSCC have not changed appreciably in the past few decades, underscoring a dire need for improved therapeutic options. Recent studies have elucidated a key signaling axis, the EGFR-STAT3-Bcl-XL signaling axis, that is aberrantly activated in a majority of HNSCC and contributes to the proliferation and survival of malignant cells. Considerable effort is being placed on developing highly specific inhibitors of different components of this pathway. This review highlights the progress that is being made towards achieving potent inhibition of the EGFR-STAT3-Bcl-XL signaling axis in HNSCC and the promising therapeutic strategies that are currently under development for this disease.