Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases

作     者：Rubaiya Tabassum Na Young Jeong Junyang Jung Rubaiya Tabassum;Na Young Jeong;Junyang Jung

作者机构：Department of Anatomy and Cell BiologyCollege of MedicineDong-A UniversityBusanKorea Department of MedicineGraduate SchoolDong-A UniversityBusanKorea Department of Anatomy and NeurobiologyCollege of MedicineKyung Hee UniversitySeoulKorea 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第4期

页      面：653-662页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science  ICT and Future Planning  No. 2018R1A2B6001123 (to NYJ)  No. 2018R1D1A1B07040282 (to JJ) 

主　　题：3-mercaptopyruvate sulfurtransferase aging antioxidant cystathionineβ-synthase cystathionineγ-lyase glutathione hydrogen sulfide neurodegenerative disease oxidative stress reactive oxygen species 

摘      要：Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated *** of the major causes of age-related diseases is oxidative *** recent years,the importance of H2S has become clear,although its antioxidant function has not yet been fully *** enzymes cystathionineβ-synthase,cystathionineγ-lya-se,and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of ***,H2S was considered a neuromodulator,given its role in long-term hippocampal potentiation,but it is now also recognized as an antioxidant in age-related *** to aerobic metabolism,the central nervous system is vulnerable to oxidative stress in brain aging,resulting in age-associated degenerative diseases.H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes,including superoxide dismutase,catalase,and glutathione peroxidase,which protect against the effects of aging by regulating apoptosis-related genes,including p53,Bax,and *** review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and Down syndrome.