Effects of environmental stressors on stem cells

作     者：Jessica R Worley Graham C Parker 

作者机构：Department of Pediatrics Wayne State University School of Medicine 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2019年第11卷第9期

页      面：565-577页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Supported by the Center for Urban Responses to Environmental Stressors Grant from the National Institute of Environmental Health Sciences No.P30 ES020957 

主　　题：Environmental substances Toxic Stem cells Endocrine disruptors Alcohols Tobacco smoking Metals Heavy Particulate matter Volatile organic compounds Ozone 

摘      要：Environmental toxicants are ubiquitous,and many are known to cause harmful health ***,much of what we know or think we know concerning the targets and long-term effects of exposure to environmental stressors is sadly *** exposure may have health effects that are currently mischaracterized or at least mechanistically incompletely *** much of the recent excitement about stem cells(SCs)focuses on their potential as therapeutic agents,they also offer a valuable resource to give us insight into the mechanisms and risks of toxicant *** only as a response to the increasing ethical pressure to reduce animal testing,SC studies allow us valuable insight into the true effects of human exposure to environmental stressors under controlled *** present a review of the history of publications on the effects of environmental stressors on SCs,followed by a consolidation of the literature over the past five years on a subset of key environmental stressors of importance to human health and their effects on both embryonic and tissue *** review will make constructive suggestions as to areas of toxicant research where further studies are needed,as well as making indications of the potential utility for advancing knowledge and directing research on environmental toxicology.