Electroacupuncture improves neuronal function by stimulation of ascending peripheral nerve conduction in rats with spinal cord injury

作     者：Song Meng Chen Wu Kamiie Junichi Okuno Seiichi Orito Kensuke 

作者机构：Laboratory of Physiology IISchool of Veterinary MedicineAzabu UniversityFuchinobeSagamiharaKanagawa 229-8501Japan Beijing Key Laboratory of Traditional Chinese Veterinary MedicineBeijing University of AgricultureBeijing 102202China Laboratory of PathologySchool of Veterinary MedicineAzabu UniversityFuchinobeSagamiharaKanagawa 229-8501Japan Veterinary Clinic of Neurology892-1 Tanaka-machiIsesakiGunma 372-0814Japan 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2019年第39卷第4期

页      面：509-515页

核心收录：

学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by a research project grant awarded by the Azabu University Research Services Division and the National Natural Science Foundation of China(No.31372473) 

主　　题：Electroacupuncture Spinal cord injuries Nerve conduction Electrophysiology Lidocaine 

摘      要：OBJECTIVE: To establish a method of transient sciatic nerve blockade and to examine the involvement of the ascending peripheral nerve pathway in the therapeutic effect of electroacupuncture at Zusanli(ST 36) in rats with spinal cord injury(SCI).METHODS: We examined the transient effect of daily lidocaine administration into the posteromedial part of the greater trochanter on sciatic nerve function using electrophysiological examination and histopathology of the sciatic nerve. Rats were divided into three groups: an SCI group(SCI without treatment), an SCI with electroacupuncture treatment(SCI-EA) group, and an SCI with nerve block and electroacupuncture(SCI-NB-EA) group(nerve block was achieved by lidocaine administration to transiently block the ascending peripheral nerve pathway). Behavioral tests and electrophysiological examinations were performed to evaluate recovery of neurological ***: Sciatic nerve conduction was normal immediately before daily lidocaine *** analysis also indicated normal sciatic nerve, confirming that lidocaine nerve blockade was suitable and reversible for transiently eliminating nerve transmission. Neurological function in the SCI-EA group was superior to that in the SCI group, while no differences were found between the SCI and SCI-NB-EA ***: Electroacupuncture treatment can promote recovery of neurological function. Facilitation of nerve conduction may play an important role in this recovery.