Synthesis and Spectroscopic Investigations of Four New Y(Ⅲ), Ge(Ⅳ), W(Ⅵ) and Si(Ⅳ) Penicillin Antibiotic Drug Complexes

作     者：Abeer A.El-Habeeb Moamen S.Refat 

作者机构：College of Science Princess Nourah Bint Abdulrahman University Department of Chemistry Riyadh 11671 Saudi Arabia Chemistry Department Faculty of Science Taif University P.O. Box 888 Al-Hawiah Taif 21974 Saudi Arabia Department of Chemistry Faculty of Science Port Said Port Said University Egypt 

出 版 物：《光谱学与光谱分析》 (Spectroscopy and Spectral Analysis)

年 卷 期：2019年第39卷第9期

页      面：2982-2988页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

主　　题：Penicillin Yttrium Germanium Tungsten Si licon FTIR Complexation Biological 

摘      要：A four new penicillinate complexes were prepared through the chemical interactio ns of penicillin potassium salt (Pin) with YCl 3, GeCl 4, WCl 6 and SiCl 4 m etal ions. These metal complexes were characterized using spectroscopic techniqu es (e.g. 1H-NMR, infrared, electronic UV-Vis) as well as elemental, cond uctivity, and magnetic measurements. The molar conductance values were highly, s howing their electrolytic nature. The magnetic and electronic study strongly rec ommends the octahedral geometry of all penicillinate complexes. A monomeric stru ctures of Pin complexes are proposed with octahedral coordinated metals ions. Th e metal ions are coordinated toward Pin as tridentate ligand through the amide a nd β-lactam carbonyls and a carboxylate group from penicillin. The in vitro antimicrobial activity of all the complexes, at concentrations in μg·mL^-1 , was screened against four bacterial pathogens, namely, Bacillus subtilis , Escherichia coli, Pseudomonas aeruginosa , and Staphylococcus aureus , and two kinds of fungi Aspergillus flavus and Candida albicans showed better activi ty compared to parent drug and control drug. The anti-cancer inhibition of the tungsten(Ⅵ) complex was assessed against the human hepato cellular carcinoma (H epG-2) tumor cell line with IC50 value is 646 μg·mL^-1 .