Can mouse models mimic sporadic Alzheimer’s disease?
Can mouse models mimic sporadic Alzheimer’s disease?作者机构：Laboratory of Psychiatry and Experimental Alzheimer’s Research Medical University of Innsbruck
出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)
年 卷 期：2020年第15卷第3期
页 面：401-406页
核心收录：
基 金：supported by the Austrian Science Funds(P24734-B24)
主 题：Alzheimer’s disease beta-amyloid cerebral amyloid angiopathy cognitive impairment sporadic and genetic mouse models tau vascular risk factors
摘 要：Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common form of dementia *** age is the main risk factor,97%of all AD cases are of sporadic origin,potentiated by various risk factors associated with life style and starting at an age60 ***3%of AD cases are of genetic origin caused by mutations in the amyloid precursor protein or Presenilins 1 or 2,and symptoms already start at an age30 *** order to study progression of AD,as well as therapeutic strategies,mouse models are *** far many transgenic mouse models have been developed and used,with mutations in the APP or presenilin or combinations(3×Tg,5×Tg).However,such transgenic mouse models more likely mimic the genetic form of AD and no information can be given how sporadic forms *** risk genes,such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD,but also many risk factors associated with life style(e.g.,diabetes,hypercholesterolemia,stress)may play a *** this review we discuss the current situation regarding AD mouse models,and the problems to develop a sporadic mouse model of AD.
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