Noninvasive assessment of liver damage in chronic hepatitis B
Noninvasive assessment of liver damage in chronic hepatitis B作者机构：Department of Gastroenterology Medical School Bozok University Department of Gastroenterology Medical School Erciyes University Department of Biostatistics and Medical Informatics Medical School Erciyes University
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2013年第5卷第8期
页 面：439-444页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Chronic hepatitis B Fibrosis Liver cirrhosis Noninvasive Serum markers
摘 要：AIM:To evaluate the efficacy of the aspartate aminotransferase/platelet ratio index(APRI)and neutrophillymphocyte(N/L)ratio to predict liver damage in chronic hepatitis B(CHB).METHODS:We analyzed 89 patients diagnosed with CHB by percutaneous liver biopsy and 43 healthy *** biopsy materials were stained with hematoxylin-eosin and Masson’s ***’fibrosis scores and histological activity index(HAI)were calculated according to the Ishak scoring *** score was recognized as follows:F0-1 No/early-stage fibrosis,F2-6 significant fibrosis,F0-4 non-cirrhotic and F5-6 *** liver fibrosis was defined as an Ishak score of≥*** and N/L ratio calculation was made by blood test ***:The hepatitis B and control group showed no difference in N/L ratios while there was a significant difference in terms of APRI scores(P0.001).Multiple logistic regression analysis revealed that the only independent predictive factor for liver fibrosis in CHB was platelet *** score was significantly higher in cirrhotic patients than in non-cirrhotic ***,this significance was not confirmed by multiple logistic regression *** optimum APRI score cut-off point to identify patients with cirrhosis was 1.01with sensitivity,specificity,positive predictive value and negative predictive value of 62%(36%-86%),74%(62%-83%),29%(13%-49%)and 92%(82%-97%),*** addition,correlation analyses revealed that N/L ratio has a negative and significant relationship with HAI(r=-0.218,P=0.041).CONCLUSION:N/L ratio was negatively correlated with *** score may be useful to exclude cirrhosis in CHB patients.
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