Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention

作     者：Huawei Zeng Darina L Lazarova Michael Bordonaro 

作者机构：United States Department of AgricultureAgricul-tural Research ServiceGrand Forks Human Nutrition Research Center Department of Basic SciencesThe Commonwealth Medical College 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2014年第6卷第2期

页      面：41-51页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by The United States Department of Agriculture 

主　　题：Dietary fiber Gut microbiota Colon cancer 

摘      要：Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carcinogens within the intestinal lumen and to promote healthy gut microbiota, which modifies the host s metabolism in various ways. Elucidation of the mechanisms by which dietary fiber-dependent changes in gut microbiota enhance bile acid deconjugation, produce short chain fatty acids, and modulate inflammatory bioactive substances can lead to a better understanding of the beneficial role of dietary fiber. This article reviews the current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer.