Effects of interleukin-1α on platelet-derived growth factor release from bovine cerebral microvascular endothelial cells
Effects of interleukin-1α on platelet-derived growth factor release from bovine cerebral microvascular endothelial cells出 版 物:《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报(英文版))
年 卷 期:1997年第12卷第1期
页 面:21-24页
学科分类:1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
主 题:interleukin-1 platelet-derived growth factor cerebral microvascular cell cell division
摘 要:The present study showed that, interleukin-1α (IL-1α) stimulateal cultured bovine cerebral microvascular endothelial cells (BCMEC) releasing growth factor which promoted bovine cerebral microvascular smooth muscle cells (BCMSMC) proliferation in a dose-dependent manner. The mitogenic activity in conditioned medium of BCMEC stimulated by IL-1α was neutralized significantly by the antibody to platelet-derived growth factor (PDGF). Imperatorin (Imp), iso-Imperatorin (iso Imp) and 6-(α,α-phenylacetylpiperazinyl)phenyl-5-methyl-4,5-dihydro-3 (2H)-pyridazinone (PMDP) did not affect the releasing of PDGF from IL-1α stimulated BCMEC, but inhibited the promotion of PDGF on the proliferation of BCMSMC. We concluded that the promotion of IL-1α on the proliferation of BCMSMC should be mediated by some growth factors, such as PDGF.