Polymorphisms of ERCC1, XPD, XRCC1 and XPG Predict Clinical Outcome in Advanced Gastric Cancer Patients Receiving Oxaliplatin-Based Chemotherapy in Chinese Population

作     者：Jian Jiang Jun Liang Ruyong Yao Qingfang Li Shanai Song Yingying Sun 

作者机构：Treatment and Research Center of Oncology The Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China. 

出 版 物：《Clinical oncology and cancer researeh》 (临床肿瘤与癌症研究)

年 卷 期：2009年第6卷第5期

页      面：328-336页

核心收录：

学科分类：080904[工学-电磁场与微波技术] 02[经济学] 0202[经济学-应用经济学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 020202[经济学-区域经济学] 

基　　金：supported by a grant from the Natural Science Foundation of Shandong Province China (No.Y2008C126) 

主　　题：gastric cancer polymorphism oxaliplatin chemotherapy ERCC1 XPD XPG XRCC1. 

摘      要：OBJECTIVE To investigate whether polymorphisms in ERCC1, XPD, XPG, XRCC1 genes are associated with clinical outcomes in advanced gastric cancer （AGC） patients treated with oxaliplatinbased chemotherapy. METHODS The genetic polymorphisms in ERCCI, XPD, XPG, XRCC1 were determined in 94 advanced gastric cancer patients treated with oxaliplatin-based chemotherapy, using TaqMan-MGB probes. The clinical response of 60 patients with stage IV disease, time to progression （TTP） and overall survival （OS） of 94 patients were evaluated. RESULTS The overall disease control rate （CR ＋ PR ＋ SD） of the 60 patients in stage IV was 70% （42/60）. Patients with XRCC1 399 G/G, XPG 46 C/C genotypes showed enhanced response to the oxaliplatin-based chemotherapy compared to those with other genotypes （P 〈 0.05）. The median OS and TTP of the patients were 5.5 months and 9.0 months, respectively. Among the 4 types of polymorphisms in the study, XRCC1 399 G/A ＋ A/A, XPG 46 C/T ＋ T/T genotypes were regarded to be associated with chemoresistance and poor survival （P 〈 0.05）. Combination analysis of the 2 polymorphisms using the Kaplan-Meier method revealed that the TTP and OS of the patients with a number of risk genotypes were significantly shortened （P 〈 0.05）. No significant association was found between the genotypes of the XPD codon 751, the ERCC1 codon 118 and the clinical outcome （P 〉 0.05）. CONCLUSION Testing for XRCC1 399, XPG 46 polymorphisms may allow identification of the gastric cancer patients who will benefit from oxaliplatin-based chemotherapy. Specific polymorphisms may influence clinical outcomes of AGC patients. Selecting specific chemotherapy based on pretreatment genotyping represents an innovative strategy that warrants prospective studies.