Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance

作     者：Jun Cao Hong Jiang Ran Zhang Amr.R.Ghanam Honghai Xia Yuting Zhu Zhen Yang Xiaoyuan Song 

作者机构：Hefei National Laboratory for Physical Sciences at the MicroscaleCAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research CenterSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of Emergency SurgeryThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Core Facility Center for Life SciencesSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230026China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2019年第64卷第16期

页      面：1132-1135页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National Key Scientific Program of China (2016YFA0100502 to X.S.) the National Natural Science Foundation of China (81701765 to J.C.) Anhui Provincial Natural Science Foundation (1808085MH295 to J.C.) 

主　　题：HCC Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance CYP 

摘      要：Cancer stem cells (CSCs) are largely responsible for the formation of tumor heterogeneity and tumor’s resistance to traditional treatments such as chemotherapy due to its self-renew capability and multi-lineage differentiation potential (1)However, it remains elusive how the CSCs maintain their stemness, thus restricting the development of therapeutic treatments specifically targeting the CSCs.