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Possible role of extracellular vesicles in exogenous chemical exposure-associated health concern

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Journal of Environmental Sciences 2019年第6期31卷 1-4页

作者： Guangbo Qu Xingchen Zhao Yanna Liu Fang Hao Jie Gao Lili Yang Qunfang Zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Environment and Health Jianghan University

Extracellular vesicles(EVs) are mediators of intercellular message communication by transferring lipids, proteins, genetic materials, and are therefore involved in a wide spectrum of physiological or pathological processes. Exogenous chemicals exposure may affect the function of EVs at the biogenesis, secretion, transport or reception stage, which could further result in abnormal information communication between cells, and thus induce toxicity and diseases. This review briefly explores the role of EVs in chemical exposure-associated health concern and progressive diseases.

关键词： EV Possible role of extracellular vesicles in exogenous chemical exposure-associated health concern

A member of the ALOG gene family has a novel role in regulating nodulation in Lotus japonicus

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Journal of Integrative Plant Biology 2019年第4期61卷 463-477页

作者： Yawen Lei Shihao Su Liang He Xiaohe Hu Da Luo State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources School of Life Sciences Sun Yat-sen University Institute of Transformative Bio-Molecules (WPI-ITbM) Nagoya University

Legumes can control the number of symbiotic nodules that form on their roots, thus balancing nitrogen assimilation and energy consumption. Two major pathways participate in nodulation: the Nod factor(NF)signaling pathway which involves recognition of rhizobial bacteria by root cells and promotion of nodulation, and the autoregulation of nodulation(AON) pathway which involves long-distance negative feedback between roots and shoots. Although a handful of genes have a clear role in the maintenance of nodule number, additional unknown factors may also be involved in this process. Here, we identify a novel function for a Lotus japonicus ALOG(Arabidopsis LSH1 and Oryza G1) family member, LjALOG1,involved in positively regulating nodulation. LjALOG1 expression increased substantially after inoculation with rhizobia, with high levels of expression in whole nodule primordia and in the base of developing nodules. The ljalog1 mutants, which have an insertion of the LORE1 retroelement in LjALOG1, had significantly fewer nodules compared with wild type, along with increased expression of LjCLE-RS1(L. japonicus CLE Root Signal 1), which encodes a nodulation suppressor in the AON pathway. In summary,our findings identified a novel factor that participates in controlling nodulation, possibly by suppressing the AON pathway.

关键词： ALOG gene novel role Lotus

Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance

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Science Bulletin 2019年第16期64卷 1132-1135页

作者： Jun Cao Hong Jiang Ran Zhang Amr.R.Ghanam Honghai Xia Yuting Zhu Zhen Yang Xiaoyuan Song Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research CenterSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of Emergency Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Core Facility Center for Life Sciences School of Life SciencesUniversity of Science and Technology of ChinaHefei 230026China

Cancer stem cells (CSCs) are largely responsible for the formation of tumor heterogeneity and tumor’s resistance to traditional treatments such as chemotherapy due to its self-renew capability and multi-lineage differentiation potential (1)However, it remains elusive how the CSCs maintain their stemness, thus restricting the development of therapeutic treatments specifically targeting the CSCs.

关键词： HCC Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance CYP

Enhancing the role of nurses in breastfeeding preterm infants

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Frontiers of Nursing 2023年第3期10卷 255-260页

作者： Yuan-Yuan Yang Jia-Yue Chen Hui-Juan Liu School of Nursing Peking UniversityBeijing 100191China Neonatal Disease Diagnosis and Treatment Center Fifth Medical Center of ChinesePeoples’s Liberation Army General HospitalBeijing 100039China

The provision of breast milk and breastfeeding is recommended for preterm infants.Multidisciplinary cooperation is required to promote breastfeeding.Nurses play impor tant roles in breastfeeding preterm infants.First,nurses are strong advocates to help families be aware of the significance of breastfeeding.Second,nurses are educators providing technical and emotional support to pregnant and lying-in women.Third,nurses are coordinators in a multidisciplinary team.Nurses’unawareness of the impor tance of breastfeeding,knowledge deficit,and unsupportive lactation policy are barriers to breastfeeding promotion for preterm infants.It is therefore suggested that hospital administrators provide appropriate breastfeeding policies,set up posts,and ensure nurses’responsibilities in breastfeeding.Additionally,tailored training should be strengthened to improve nurses’knowledge and skills and thereby enable them to fully exer t their roles in the breastfeeding promotion of preterm infants.

关键词： breastfeeding nurses preterm infants review role

Detrimental and synergistic role of epilepsy——Alzheimer’s disease risk factors

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Neural Regeneration Research 2019年第8期14卷 1376-1377页

作者： Mikhail A. Filippov Vasily V. Vorobyov International Medical Cluster Skolkovo Moscow Region Russia Institute of Cell Biophysics Russian Academy of Sciences Pushchino Moscow Region Russia

Identification of individuals at risk for developing Alzheimers disease (AD) is an important issue for its pretreatment. Perspective studies predicting the disease are based on the genetic approaches emerging from the nucleotide polymorphism analysis in different loci through the entire genome in AD patients. Considerable diversity of genes located in these regions raise the question of this diversity's peculiar role in the disease development. The mechanisms of AD have been shown to be associated with the gene variation, increased beta-amyloid production and concomitant epileptiform activity/epilepsy in particular (Palop and Mucke, 2009).

关键词： Detrimental synergistic role disease risk factors

Jack of Many Trades: The Multifaceted role of miR528 in Monocots

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Molecular Plant 2019年第8期12卷 1044-1046页

作者： Chengjie Chen Yuanlong Liu Rui Xia State Key Laboratory for Conservation and Utilization of Subtropical AgroBioresources College of HorticultureSouth China Agricultural UniversityGuangzhou 510642China

MicroRNAs (miRNAs) are essential regulators,involved in almost all aspects of plant growth and development.In plants,miRNAs prese nt in all an giosperms are regarded as con served miRNAs;in contrast,miRNAs restricted to certain lineages (lessconserved) or a single species (species-specific) constitute the non-conserved miRNAs (Cuperus et al.,2011).Different members of a miRNA family usually target similar target genes from a gene family among different species.For in stance,in most analyzed plants,the well-known miR156 family,usually consist!ng of a number of members in a given species,collectively target SQUAMOSA-PROMOTER BINDING PROTEINLIKE (SPL) genes.Gen erally,con served miRNAs target genes encoding transcript factors which function in diverse biological processes.This functional diversity of miRNAs is mainly achieved by the plasticity of their target genes from the same family,such as miR156-targeted SPLs and miR167-targeted ARF (AUXIN RESPONSIVE FACTOR) genes,on regulating distinct downstream gen es.

关键词： Multifaceted role miR528 Monocots

The experience of transition from nursing students to newly graduated registered nurses in Singapore

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International Journal of Nursing Sciences 2020年第1期7卷 81-90页

作者： Ming Wei Jeffrey Woo Stuart Andrew Newman School of Health&Social Sciences Nanyang PolytechnicSingapore Susan Wakil School of Nursing and Midwifery The University of SydneyNew South WalesAustralia

Objectives:To investigate the experience of newly graduated registered nurses(NGRNs)in Singapore following their initial 6-12 months of transition from nursing student to registered nurse.Methods:This mixed-methods study consisted of two phases.In the first phase,data were collected via the administration of the online survey to 30 NGRNs.The questionnaire contained 42 items of the fourpoint Likert scale survey.In the second phase,a focus group interview was conducted with 5 NGRNs to gather complementary information regarding the major findings from the first phase.Results:The survey revealed despite most NGRNs(80%)in this study expressed overall satisfied with their transition,the item score was(2.97±0.61)out of 4,the majority(83.3%)also perceived their transition to professional practice being stressful,the item score was(3.07±0.74)out of 4.Three themes emerged from the interview,'personal transition experience','professional transition experience',and'organizational transition experience',which are entwined to construct overall NGRNs'transition experiences.Conclusions:This study reaffirms the theory-practice gap phenomenon.This signifies the need for closer collaboration between educational,healthcare industry and regulatory stakeholders to examine and address factors that influence their transition experience to better support them for workforce readiness.

关键词： Hospital nursing staff Nursing students role Singapore

Visible-light-activated N-doped CQDs/g-C3N4/Bi2WO6 nanocomposites with different component arrangements for the promoted degradation of hazardous vapors

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Journal of Materials Science & Technology 2020年第5期40卷 168-175页

作者： Mi Gyeong Kim Wan-Kuen Jo Department of Environmental Engineering Kyungpook National University 80 University RoadBukguDaegu702-701Republic of Korea

To investigate whether the arrangement of componentsin multi-composite photocatalysts may affect their photocatalytic properties,due to different charge-transfer routes,two ternary-nanocomposite photocatalysts with different component arrangements,comprising N-doped carbon quantum dots(NCQDs),g-C3N4(CN),and Bi2WO6(BWO)(hereafter referred to as NCQDs/CN/BWO),were developed,and the photocatalytic degradation of model hazardous vapors under visible-light illumination was investigated.Type I NCQDs/CN/BWO,which was developed by the combination of NCQDs/BWO and CN,exhibited photocatalytic ability superior to that of type II NCQDs/CN/BWO,which was developed by the combination of CN/BWO and NCQDs;the superior photocatalytic ability corresponded to the dual properties of NCQDs:charge mediation and upconversion photoluminescence.Moreover,the photocatalytic ability of NCQDs/CN/BWO was greater than those of the reference catalysts;in addition,this photocatalyst exhibited outstanding photochemical stability.Additionally,the effects of CN/(BWO+CN)weight ratio of the CN/BWO dual nanocomposites and the NCQDs/(BWO+CN+NCQDs)weight percentage of NCQDs/CN/BWO ternary nanocomposites on the pollutant removal efficiency were investigated.The plausible mechanisms over the two NCQDs/CN/BWO photocatalysts for the degradation of hazardous vapors were discussed.The component arrangement approach proposed herein afforded a technique toward the perceptive development of novel multi-component heterostructures for the photocatalytic degradation of hazardous vapors.

关键词： Component arrangement Charge-transfer route NCQDs dual role Charge mediator Upconversion photoluminescence

Emerging role of Hippo pathway in gastric and othergastrointestinal cancers

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World Journal of Gastroenterology 2016年第3期22卷 1279-1288页

作者： Wei Kang Alfred SL Cheng Jun Yu Ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory in Oncology in South ChinaLi Ka Shing Institute of Health ScienceSir Y.K.Pao Cancer CenterInstitute of Digestive DiseasePartner State Key Laboratory of Digestive DiseasePrince of Wales HospitalThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Institute of Digestive DiseasePartner State Key Laboratory of Digestive DiseasePrince of Wales HospitalThe Chinese University of Hong KongHong KongChina

More evidence has underscored the importance of Hippo signaling pathway in gastrointestinal tissue homeostasis, whereas its deregulation induces tumorigenesis. Yes-associated protein 1(YAP1) and its close paralog TAZ, transcriptional co-activator with a PDZbinding motif, function as key effectors negatively controlled by the Hippo pathway. YAP1/TAZ exerts oncogenic activities by transcriptional regulation via physical interaction with TEAD transcription factors. In various cancers, Hippo pathway cross-talks with pro- or anti-tumorigenic pathways such as GPCR, Wnt/β-catenin, Notch and TGF-β signaling and is deregulated by multiple factors including cell density/junction and micro RNAs. As YAP1 expression is significantly associated with poor prognosis of gastric and other gastrointestinal cancers, detailed delineation of Hippo regulation in tumorigenesis provides novel insight for therapeutic intervention. In current review, we summarized the recent research progresses on the deregulation of Hippo pathway in the gastrointestinal tract including stomach and discuss the molecular consequences leading to tumorigenesis.

关键词： Hippo signaling pathway Yes-associatedprotein 1 MicroRNA Oncogenic role Tumor suppressor