Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway
Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway作者机构：Department of Infectious DiseasesAffiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Hepatobiliary SurgeryAffiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Comprehensive Liver Cancer Center302 HospitalBeijing 100039China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2019年第25卷第30期
页 面：4222-4234页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the National Natural Science Foundation of China No.81560104 and No.81860115
主 题：Liver fibrosis Bone morphogenetic protein Transforming growth factor Hepatic stellate cells
摘 要：BACKGROUND Liver fibrosis is a refractory disease whose persistence can eventually induce cirrhosis or even liver *** liver fibrosis is reversible by *** a member of the transforming growth factor-beta(TGF-β)superfamily,bone morphogenetic protein 7(BMP7)has anti-liver fibrosis ***,little is known about BMP7 expression changes and its potential regulatory mechanism as well as the relationship between BMP7 and TGF-βduring liver *** addition,the mechanism underlying the anti-liver fibrosis function of BMP7 needs to be further *** To investigate changes in the dynamic expression of BMP7 during liver fibrosis,interactions between BMP7 and TGF-β1,and possible mechanisms underlying the anti-liver fibrosis function of *** Changes in BMP7 expression during liver fibrosis and the interaction between BMP7 and TGF-β1 in mice were *** BMP7 was used to treat mouse primary hepatic stellate cells(HSCs)to observe its effect on activation,migration,and proliferation of HSCs and explore the possible mechanism underlying the anti-liver fibrosis function of *** with liver fibrosis received exogenous BMP7 intervention to observe improvement of liver fibrosis by using Masson’s trichrome staining and detecting the expression of the HSC activation indicator alpha-smooth muscle actin(α-SMA)and the collagen formation associated protein type I collagen(Col I).Changes in the dynamic expression of BMP7 during liver fibrosis in the human body were further *** In the process of liver fibrosis induced by carbon tetrachloride(CCl4)in mice,BMP7 protein expression first increased,followed by a decrease;there was a similar trend in the human *** process was accompanied by a sustained increase in TGF-β1 protein *** vitro experiment results showed that TGF-β1 inhibited BMP7 expression in a time-and dose-dependent *** contrast,high doses of exogenous BMP7 inhibited TGF-β1-induced activation
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