Erosion-Induced Inflammation on Coronary Plaque Stress/Strain and Flow Shear Stress Calculations Using OCT-Based FSI Computational Model

作     者：Liang Wang Luping He Rui Lv Xiaoya Guo Chun Yang Haibo Jia Dalin Tang 

作者机构：School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China Department of CardiologyThe 2nd Affiliated Hospital of Harbin Medical UniversityHarbin150086China Department of MathematicsSoutheast UniversityNanjing210096China Network Technology Research InstituteChina United Network Comm.Co.Ltd.BeijingChina Mathematical Sciences DepartmentWorcester Polytechnic InstituteWorcesterMA01609USA 

出 版 物：《医用生物力学》 (Journal of Medical Biomechanics)

年 卷 期：2019年第34卷第A1期

页      面：112-113页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100106[医学-放射医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：supported in part by NSFC ( 11672001,11802060) Jiangsu NSF ( BK20180352) Jiangsu Province Science and Technology Agency ( BE2016785) 

主　　题：plaque erosion inflammation fluid-structure interaction OCT acute coronary syndrome 

摘      要：Plaque erosion,together with plaque rupture,is a common cause for acute coronary syndrome(ACS).Plaque erosion alone is responsible for about one third of the patients with *** plaque is defined as thrombosed,endothelium-absent and non-ruptured but often-inflamed plaques based on histological *** though there is efficient imaging technologies to detect the eroded plaque in vivo and tailored treatment strategy has also been developed for ACScaused by erosion in clinics,the pathogenesis mechanisms that cause plaque erosion are not fully *** is widely postulated that thrombus formation and endothelial apoptosis(the precursors of plaque erosion)have closed association with biomechanical conditions in the coronary *** of the mechanical conditions in the eroded plaque could advance our knowledge in understanding the formation of plaque *** this end,patient-specific OCT-based fluid-structure interaction(FSI)models were developed to investigate the plaque biomechanical conditions and investigate the impact of erosioninduced inflammation on biomechanical *** vivo OCTand Biplane X-ray angiographic data of eroded coronary plaque were acquired from one male patient(age:64). OCT images were segmented manually with external elastic membrane contour and the trailing edge of the lipid-rich necrotic core(lipid)assumed to have positive remodeling ratio *** with luminal surface having direct contact with intraluminal thrombus on OCT images were identified erosion *** of OCT and biplane X-ray angiographic data were performed to obtain the 3D coronary ***-based FSI models with pre-shrink-stretch process and anisotropic material properties were constructed following previously established *** reflect tissue weakening caused by erosion-induced inflammation,the material stiffness of plaque intima at the erosion site was adjust to one tenth of un-eroded fibrous plaque *** FSI models were c